当归承气汤对躁狂症患者生活质量的影响  

Effects of Danggui Chengqi Decoction on Patients' Quality of Life of Mania

作　　者：龙彬 朱丽萍[1] 吴海苏[1] 张建明[1] 卢卫红 茅永骏 岳英[3] 陆国平[3] 饶顺曾[4] 汪作为[5] 赵敏[1] 

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海201108 [2]上海市闵行区精神卫生中心,上海201100 [3]上海市黄浦区精神卫生中心,上海200003 [4]上海市徐汇区精神卫生中心,上海200030 [5]上海市虹口区精神卫生中心,上海200083

出　　处：《辽宁中医杂志》2015年第2期239-243,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：上海市科学技术委员会中药现代化专项基金资助项目(11DZ1972800)

摘　　要：目的:探讨当归承气汤对躁狂症患者生活质量的影响。方法:应用随机、双盲、病例对照研究方法,将123例患者随机分成当归承气汤组41例、碳酸锂组42例和当归承气汤合并碳酸锂组40例,分别使用当归承气汤、碳酸锂、当归承气汤合并碳酸锂治疗,疗程8周,在基线、2周、4周和8周末时,对Young氏躁狂量表(YMRS)、副反应量表(TESS)及健康状况问卷(SF-36)等进行评定。结果:YMRS评分3组在治疗前与治疗后2周、4周及8周比较差异均有统计学意义(P<0.01);3组之间比较,YMRS总分在治疗2周、4周后当归承气汤组与当归承气汤合并碳酸锂组比较差异有统计学意义(P=0.004、P=0.001),治疗8周后3组之间两两比较差异均有统计学意义(P<0.01)。治疗前后比较当归承气汤组在精神健康(MH)条目评分差异无统计学意义(P>0.05),其余条目量表评分比较差异均有统计学意义(P<0.01),碳酸锂组和当归承气汤合并碳酸锂组在躯体功能(PF)、躯体健康问题导致的角色受限(RP)、躯体疼痛(BP)、总体健康感(GH)、生命活力(VT)、社交功能(SF)、情感问题所致的角色受限(RE)、精神健康(MH)、健康变化自评(HT)、躯体健康总评(PCS)和精神健康总评(MCS)治疗前后差异有统计学意义(P<0.01)。治疗后3组之间两两比较在PF条目评分差异均无统计学意义(P>0.05),RP、GH、SF、MCS量表评分比较差异有统计学意义(P<0.01),BP量表评分比较当归承气汤组与当归承气汤合并碳酸锂组差异有统计学意义(P=0.004),VT、RE、MH、HT、PCS量表评分3组间两两比较差异有统计学意义(P<0.01)。治疗后2、4、8周末TESS总分当归承气汤组显著低于碳酸锂组、当归承气汤合并碳酸锂组,差异有统计学意义(P<0.01)。结论:当归承气汤合并碳酸锂治疗躁狂症可以提高疗效,有效改善躁狂症患者的生活质量,减少不良反应。Objective：To explore effect Danggui Chengqi Decoction on the quality of life of mania patients.Methods：123 patients meeting the criteria of CCMD-3 for maina were randomly divided into three groups,the lithium carbonate group（n = 42）,the Danggui Chengqi Decoction group（n = 41） and Danggui Chengqi Decoction combined with lithium carbonate group（n =40）.Maina patients were given Danggui Chengqi Decoction and lithium carbonate and placebo respectively for 8 weeks.Clinical efficacy and the safety were evaluated with Young Mania Rating Scale（YRMS） and treatment emergent symptoms scale（TESS）separately.The short form health survey（SF-36） was measured at the baseline and 8th week after treatment to evaluate the quality of life.Results：At the end of 2nd,4th,8th week after Young Mania Rating Scale,the total scores showed significance in each group（P〈0.01）.There were significant differences in Young Mania Rating Scale＇s total scores at the end of 2nd and 4th week after treatment between the Danggui Chengqi Decoction group and the Danggui Chengqi Decoction combined with lithium carbonate group（P = 0.004,P = 0.001）.There were significant differences in Young Mania Rating Scale＇s total scores at the end of 8th week after treatment between the Danggui Chengqi Decoction group and the Danggui Chengqi Decoction combined with lithium carbonate group as well as between the lithium carbonate group and the Danggui Chengqi Decoction combined with lithium carbonate group（P〈0.01）.There were significant differences in the scores of PF,RP,BP,GH,VT,SF,RE,HT,PCS and MCS after treatment in the Danggui Chengqi Decoction group（P〈0.01） while there was no statistical difference in the scores of MH（P〉0.05）.There were significant differences in the scores of PF,RP,BP,GH,VT,SF,RE,MH,HT,PCS and MCS in the Danggui Chengqi Decoction group and the Danggui Chengqi Decoction combined with lithium carbonate group（P〈0.01）.There were significant differences in the scores of RP,GH,SF and MCS af

关 键 词：当归承气汤 躁狂症 生活质量 

分 类 号：R277.7[医药卫生—中医学]