异基因造血干细胞移植期间患者营养状态及其影响因素的分析  

Nutritional status and its related factors in patients undergoing allogenetic hematopoietic stem cell transplantation

作　　者：郝素娟[1] 李惠玲[1] 景秀琛[2] 朱霞明[3] 杨晶[4] 陆茵[3] 

机构地区：[1]苏州大学护理学院,215006 [2]苏州大学附属第一医院护理部 [3]苏州大学附属第一医院血液科 [4]苏州大学附属第一医院营养科

出　　处：《中国实用护理杂志》2015年第3期161-165,共5页Chinese Journal of Practical Nursing

基　　金：江苏省高校自然科学研究面上项目（13KJB320023）

摘　　要：目的调查异基因造血干细胞移植期间患者的营养状态，分析相关因素，为该类人群的营养管理提供依据。方法采用便利抽样法选择在苏州市某三级甲等医院行异基因造血干细胞移植的患者75例作为研究对象，应用HSCT患者基本资料调查表、PG-SGA量表对其进行营养评估，分析影响患者营养状态的相关因素。结果预处理开始后4周内患者前白蛋白水平呈先升高后下降的趋势；体质量和体重指数一直呈下降趋势。PG-SGA评估结果显示，预处理前患者营养不良发生率为29．33％，营养评分为（5．60±4．96）分，有33．3％的患者存在饮食问题；预处理开始后第2周营养不良发生率为85．33％，营养评分为（19．26±7．18）分，有93．2％的患者存在饮食问题；第4周营养不良发生率为85．33％，营养评分为（12．95±6．19）分，有75．8％的患者存在饮食问题。年龄是影响患者第2周前白蛋白水平的主要因素。结论异基因造血干细胞移植期间患者营养状态下降，营养不良比例增高。临床医务人员应加强该类人群营养状态的评估，必要时给予合理的营养支持，为移植的顺利进行提供保障。Objective We tried to investigate the nutritional status and related factors in patients undergoing allogenetic hematopoietic stem cell transplantation. Methods A total of 75 patients were re- cruited from a class-three hospital in Suzhou. They were investigated with a basic information questionnaire and the Patient-Generated-Subjective Global Assessment （PG-SGA）. The related factors influencing nutri- tional status were analyzed. Results The PAB level began to rise since conditioning regimen, and it rose to the highest level in the second week, then began to decline. The weight and the BMI had been declining in the four weeks since conditioning regimen. 29.33% of the patients were malnourished, the scored PG- SGA was （5.60± 4.96）, the percentage of patients with dietary problems was 33.3% before conditioning regi- men; 85.33% of the patients were malnourished, the scored PG-SGA was （19.26±7.18）, the percentage of patients with dietary problems was 93.2% in the second week since conditioning regimen; 85.33% of the patients were malnourished, the scored PG-SGA was （12.95±6.19）, the percentage of patients with dietary problems was 75.8% in the fourth week; Age is the main factor affecting the patients＂ albumin level in the second week. Conclusions The nutritional status of patients deteriorated and the percentage of patients with malnutrition increased during allogeneic hematopoietic stem cell transplantation. Clinical staff should pay atten- tion to the assessment of nutritional status, and give a reasonable nutritional support when necessary.

关 键 词：异基因造血干细胞移植 营养状态 营养评估 

分 类 号：R459.3[医药卫生—治疗学]