高同型半胱氨酸血症与阿尔茨海默病精神障碍的相关性分析  

The Correlation of Hyperhomocysteine and Behaviral and Psychological Symptoms of Dementia

作　　者：郑占杰[1] 陈红[1] 王金东[1] 衣磊[1] 于慧[1] 孔伶俐[1] 崔维珍[1] 

机构地区：[1]山东省青岛市精神卫生中心,中国266034

出　　处：《中国健康心理学杂志》2015年第1期4-8,共5页China Journal of Health Psychology

基　　金：青岛市卫生局立项课题资助项目(编号:2010-WSZD068)

摘　　要：目的:探讨高同型半胱氨酸血症与阿尔茨海默病精神障碍(BPSD)的相关性。方法:对77例阿尔茨海默病(AD)患者(BPSD组40例,非BPSD组37例)及39例正常对照者进行血浆同型半胱氨酸(Hcy)测定,并分析其与BPSD、认知功能障碍及痴呆病程的关系。结果:1BPSD组和非BPSD组血浆Hcy明显高于正常组(P<0.001),且BPSD组显著高于非BPSD组(P<0.001);2 Hcy水平与认知功能障碍(rBPSD组=0.974,P<0.001;r非BPSD组=0.929,P<0.001)、痴呆病程(rBPSD组=0.988,P<0.001;r非BPSD组=0.974,P<0.001)密切相关,但未发现BPSD与认知功能障碍及痴呆病程的相关性。结论:高同型半胱氨酸血症可能参与BPSD的发病机制。Objective： To investigate the correlation between hyperhomocysteine and Behaviral and Psychological Symptoms of Dementia（ BPSD）. Methods： Plasma homocysteine（ Hcy） was measured in 77 patients with Alzheimer disease（ AD）（ BPSD group of 40 cases,non- BPSD group of 37 cases） and 39 normal controls. The correlation between plasma homocysteine levels and BPSD,cognitive impairment,duration of dementia were analyzed. Results： 1 The plasma Hcy levels were significantly higher in BPSD and non- BPSD group than that in the normal group（ P 0. 001）,and the BPSD group was significantly higher than non- BPSD group（ P 0. 001）. 2 There was a significantly correlation between Hcy levels and cognitive decline（ rBPSD grou= 0. 974,P 0. 001; rNo- BPSD grou= 0. 929,P 0. 001） and duration of dementia（ rBPSD grou= 0. 988,P 0. 001; rNo- BPSD grou= 0. 974,P 0. 001）,but no correlation between BPSD and cognitive dysfunction and duration of dementia. Conclusion： Hyperhomocysteine may take part in the pathogenesis of BPSD.

关 键 词：阿尔茨海默病 精神行为症状 同型半胱氨酸 简易智能精神状态量表 

分 类 号：R395.1[哲学宗教—心理学] R749.1[医药卫生—医学心理学]