不同病期慢性HBV感染者肝功能、HBV-DNA与HBV-M模式的关系  

Relationships between HBV-M patterns and liver function,HBV-DNA in patients with chronic HBV infection of different stages

作　　者：曾雅莉[1] 马清峰[1] 熊微[1] 熊亮[1] 

机构地区：[1]华中科技大学同济医学院附属梨园医院检验科,湖北武汉430077

出　　处：《国际检验医学杂志》2015年第4期433-435,共3页International Journal of Laboratory Medicine

基　　金：中央高校基本科研业务费专项基金资助项目(2014QN077)

摘　　要：目的探讨慢性乙型肝炎病毒(HBV)感染者不同病期乙型肝炎五项指标(HBV-M)模式的分布及其与肝功能和HBV-DNA载量的关系。方法采集456例慢性HBV感染者血清标本,定量检测HBV-M、肝功能及HBV-DNA载量;根据病期不同将患者分为慢性乙型肝炎组(包括轻度、中度、重度亚组),肝硬化组(包括代偿亚组、失代偿亚组)和肝癌组。结果 3组间HBsAg、HBeAg、HBcAb阳性模式(135模式)和HBsAg、HBeAb、HBcAb阳性模式(145模式)所占比例比较,差异有统计学意义(P<0.05)。慢性乙型肝炎各亚组135模式的丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)水平高于另两种模式,差异有统计学意义(P<0.05);肝硬化各亚组和肝癌组中,3种HBV-M模式的清蛋白(ALB)和总胆红素(TBIL)水平进行比较,差异有统计学意义(P<0.05)。各组135模式HBV-DNA载量均高于另两组,差异有统计学意义(P<0.05)。结论随着慢性乙型肝炎病情的进展,135模式的比例呈现下降趋势,145模式的比例呈上升趋势;在区分HBV慢性感染者病期的情况下,ALT、AST、ALB、TBIL水平及HBV-DNA载量与HBV-M模式密切相关。Objective To investigate the distribution of five indicators of hepatitis B（HBV-M）and its relationship with liver function parameters and HBV-DNA load in patients with chronic HBV infection in different stages.Methods The serum samples were collected from 456 patients infected with HBV.The HBV-M,liver functional parameters and HBV-DNA level were quantitatively detected.According to the stages of disease,the patients were divided into 3groups including chronic hepatitis B group（including mild subgroup,moderate subgroup and severe subgroup）,liver cirrhosis group（including compensatory subgroup,decompensated subgroup）and hepatocellular carcinoma goup.Results The ratio of HBsAg,HBeAg,HBcAb positive pattern（135pattern）and HBsAg,HBeAb,HBcAb positive pattern（145pattern）in the three groups were statistically different（P〈0.05）.In each chronic hepatitis B subgroup,both ALT and AST levels of 135 pattern were significantly higher than the other two patterns（P〈0.05）.In each liver cirrhosis subgroup and hepatocellular carcinoma group,there were statistically significant differences in ALB and TBIL levels between the three patterns（P〈0.05）.In each group,the HBV-DNA level of 135 positive pattern were significantly higher than the other two patterns（P〈0.05）.Conclusion With the advancement of chronic hepatitis B,there is a downtrend in the ratio of 135 pattern and increasing trend in the ratio of 145 pattern.If the stage of hepatitis B is discriminated,ALT,AST,ALB TBIL and HBV-DNA level were closely related to HBV-M pattern.

关 键 词：乙型肝炎病毒 肝炎 肝硬化 肝癌 

分 类 号：R512.62[医药卫生—内科学]