孕妇产检尿液细菌培养分离菌株的分布及药物敏感性分析  

The distribution of bacteria strains isolated from urine samples of pregnant women and drug sensitivity analysis

作　　者：赵海蓉[1] 杜艳[2] 邵天波[2] 许云敏[2] 陈正辉[2] 陈瑞春[2] 

机构地区：[1]云南省绥江县人民医院检验科,云南绥江657700 [2]昆明医科大学第一附属医院检验科,云南昆明650032

出　　处：《国际检验医学杂志》2015年第4期456-457,460,共3页International Journal of Laboratory Medicine

摘　　要：目的了解孕妇尿路感染病源菌群分布及其主要病原菌的耐药状况。方法收集孕妇产检尿液标本,进行细菌培养分离,采用VITEK2全自动细菌分析仪进行鉴定,对大肠埃希菌、无乳链球菌进行药敏试验并分析。结果 2011年和2012年尿液标本培养阳性率分别为4.4%和3.8%,分离出的病源菌数量均排在前五位的分布为大肠埃希菌、无乳链球菌、粪肠球菌、肺炎克雷伯菌、变形杆菌。2年中,大肠埃希菌对其耐药率持续大于50%的抗菌药物为氨苄西林和派拉西林,产超广谱β-内酰胺酶(ESBLs)的大肠埃希菌检出率2012年较2011年有所降低,无乳链球菌对红霉素和克林霉素的耐药率均大于30%。结论孕妇尿路感染的病原菌中大肠埃希菌所占比例最大,病原菌对常见的抗菌药物均存在不同程度的耐药性。Objective To investigate the distribution characteristics and drug resistance of pathogens isolated from pregnant woman′s urine samples.Methods The urine samples of pregnant women who underwent prenatal examination were collected and cultured.VITEK2 automatic bacterial analyzer was used to identify the bacteria strains,and Escherichia coli,Streptococcus agalactiae were tested for their drug susceptibility.Results The positive rates of urine culture were 4.4%和3.8% respectively in 2011 and 2012.The top 5most isolated strains were Escherichia coli,S.agalactiae,Enterococcus faecalis,K.pneumoniae and Propeus vulgaris.In 2011 and 2012,the resistance rates of Escherichia coli to ampicillin and piperacillin was more than 50%,ESBLs-producing rate in Escherichia coli had decreased in 2012 than 2011,the resistance rates of S.agalactiae to erythromycin and clindamycin were more than 30%.Conclusion Escherichia coli accounted for the largest proportion in the strains isolated from urine samples of pregnant women,The pathogen of urinary tract infection in pregnant women are still mainly Gram-negative bacteria（Escherichia coli）,the main pathogens common antibiotics are varying degrees of resistance,pathogens all display common drug resistance of varying degrees.

关 键 词：大肠埃希菌 无乳链球菌 抗菌药物耐药性 尿液 产前检查 

分 类 号：R446.5[医药卫生—诊断学]