不同人群sdLDL-C水平及其与血脂组分的相关性分析  

SdLDL-C levels of different populations and its correlation with lipid components

作　　者：黎晓绮[1] 郭翼华[1] 熊燕[1] 陈世友[2] 

机构地区：[1]江门市人民医院检验科,广东529000 [2]江门市人民医院保健科,广东529000

出　　处：《国际检验医学杂志》2015年第4期472-474,共3页International Journal of Laboratory Medicine

基　　金：江门市科技计划项目([2014]72-10)

摘　　要：目的调查不同人群小而密低密度脂蛋白胆固醇(sdLDL-C)水平,分析其与血脂组分的相关性。方法选取于该院进行体检和门诊就医人员共986例作为研究对象。其中血脂正常者654例,并根据性别和年龄划分;血脂增高者根据空腹TG和LDL-C分为高TG组、高LDL-C组、联合增高组。测定上述人群血清sdLDL-C、LDL-C、TG、TC、HDL-C、ApoAⅠ和ApoB水平,并分析sdLDL-C与TG、TC、HDL-C、ApoAⅠ、ApoB的相关性。结果男、女sdLDL-C 70岁之后开始下降,差异有统计学意义(P<0.05);sdLDL-C水平总体均值男性高于女性,差异有统计学意义(P<0.05)。各血脂增高组sdLDL-C水平、sdLDL-C/LDLC均高于血脂正常组,差异均有统计学意义(P<0.05)。sdLDL-C与TC、TG、ApoB呈正相关(r分别为0.254、0.589、0.302),与HDL-C和ApoAⅠ呈负相关(r分别为-0.421、-0.275、-0.311)。结论sdLDL-C与TC、TG、ApoB呈正相关,与HDL-C、ApoAI呈负相关,能较准确地反映机体脂质代谢整体状况。Objective To survey small dense low-density lipoprotein cholesterol（sdLDL-C）distribution among different populations,and analyze its relationship with lipid component.Methods 986 cases of people who underwent medical examination in the hospital were recruited in the study.There were 654 people with normal concentrations of serum blood lipids（normal blood lipids group）,according to sex and age they were divided into groups.The people whose serum lipids concentrations increased above the normal range were divided into TG increasing group,LDL-C increasing group and joint increasing group according to the type of lipids componet increased.Serum sdLDL-C,LDL-C,TG,TC,HDL-C,ApoAⅠ and ApoB were determind in the people mentioned above,and the correlation between sdLDL-C and TG,TC,HDL-C,ApoAⅠ,ApoB concentrations were analyzed.Results SdLDL-C began to decline after the age of 70,the difference was statistically significant（P〈0.05）;the ensemble average of the males was higher than that of females,the difference was statistically significant（P〈0.05）.The serum sdLDL-C cocentrations of all the serum lipis increasing groups were significantly higher than those of normal blood lipids group,the difference was statistically significant（P〈0.05）.SdLDL-C concentrations were positively correlated with TC,TG,ApoB（r=0.254,0.589,0.302）,and was negative correlated with HDL-C and ApoAⅠ（r=-0.421,-0.275,-0.311）.Conclusion There was a positive correlation between sdLDL-C and TC,TG,ApoB,and sdLDL-C was negatively correlated with HDL-C,ApoAⅠ,which can accurately reflect the overall status of lipid metabolism.

关 键 词：小而密低密度脂蛋白胆固醇 血脂 相关性分析 

分 类 号：R446.1[医药卫生—诊断学]