肿瘤坏死因子-α基因G-238A多态性与冠状动脉疾病相关性的Meta分析  

Correlation between G-238A polymorphism of tumor necrosis factor-α and coronary artery disease:a Meta-analysis

作　　者：华先平[1] 王贤明[2] 谢建[1] 操传斌[1] 钱进[1] 彭俊秋[1] 张振建[1] 

机构地区：[1]湖北医药学院附属随州市中心医院心血管内科二病区,随州441300 [2]湖北医药学院附属随州市中心医院超声科,随州441300

出　　处：《中国循证心血管医学杂志》2015年第1期23-26,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的采用Meta分析的方法探讨肿瘤坏死因子-α（TNF-α）基因G-238A多态性与冠状动脉疾病（CAD）风险的相关性。方法检索Pub Med、Embase和中国知网数据库,收集探讨TNF-α基因G-238A多态性与CAD风险的相关性的病例-对照研究,检索时限均从建库至2014年5月13日。由两名研究者独立选择筛选文献、提取资料后,使用Comprehensive Meta-Analysis软件进行Meta分析。结果最终10篇文献共11项病例-对照研究。Meta分析结果表明G-238A多态性与CAD风险相关性无统计学意义[A vs.G：OR=1.08,95%CI：0.89~1.30,I2=34.33%;AA vs.GG：OR=1.15,95%CI：0.59~2.25,I2=0%;GA vs.GG：OR=1.14,95%CI：0.88~1.48,I2=54.34%;AA vs.（GG＋GA）：OR=1.09,95%CI：0.56~2.14,I2=0%;（GA＋AA）vs.GG：OR=1.11,95%CI：0.90~1.38,I2=41.92%]。敏感度分析显示研究结果稳定性较好。亚组分析同样得到了类似结果。未检测到发表偏倚。结论 TNF-α基因G-238A多态性与CAD易感性可能无相关性,建议开展高质量研究进一步论证。Objective To investigate the correlation between G-238A polymorphism of tumor necrosis factor- a （TNF- a） and risk of coronary artery disease （CAD） by applying Meta-analysis. Methods The databases of PubMed, EMbase and CNKI were retrieved for collecting the case-control studies on correlation between G-238A polymorphism of TNF- ct and CAD risk from database establishment time to May 13, 2014. After screening literature and extracting data by 2 independent researchers, the data was given a Meta-analysis by using Comprehensive Meta-Analysis software. Results There were finally 11 case-control studies included in 10 literature. The results of Meta-analysis showed that the correlation between G-238A polymorphism and CAD risk had no statistical significance [A vs. G： OR=l.08, 95%C1： 0.89-1.30,I2=34.33%; AA vs. GG： OR=l.15, 95%CI： 0.59-2.25,I2=0%; GA vs. GG： OR=l.14, 95%CI： 0.88~1.48,I2=54.34%; AA vs. （GG＋GA）： OR=l.09, 95%CI： 0.56~2.14, I2=0%; （GA＋AA） vs. GG： OR-1.11, 95%CI： 0.90-1.38,I2=41.92%]. The sensitivity analysis showed that all results were robust, and subgroup analysis had the similar results. No publication bias was detected. Conclusion G-238A polymorphism of TNF, ct maybe not correlated to CAD risk. It is suggested to conduct more higher-quality studies for further verification.

关 键 词：肿瘤坏死因子 多态性 冠状动脉疾病 冠心病 META分析 

分 类 号：R543.3[医药卫生—心血管疾病]