白介素-6和降钙素原预测糖尿病足溃疡患者截肢的价值  

Predictive value of interleukin-6 and procalcitonin for lower extremity amputation in patients with diabetic foot ulcers

作　　者：何银辉[1] 徐海燕[1] 杨如会[2] 孙霞[1] 陈凯[1] 

机构地区：[1]丽水市中心医院,浙江大学丽水医院,温州医科大学附属第五医院内分泌科,浙江丽水323000 [2]丽水学院医学与健康学院,浙江丽水323000

出　　处：《温州医学院学报》2015年第2期112-114,118,共4页Journal of Wenzhou Medical College

基　　金：浙江省医药卫生科技计划资助项目(2013KYA236)

摘　　要：目的:分析糖尿病足溃疡患者截肢的临床和实验室相关危险因素,探讨白介素-6和降钙素原能否预测糖尿病足溃疡患者的截肢。方法:45例糖尿病足溃疡患者纳入本研究,患者人口学特征及创面情况均由专人记录。入院时白介素-6和降钙素原抽血检验。结果:12例(占26.7%)糖尿病足溃疡患者最终截肢。和非截肢组相比,截肢组既往截肢史(P=0.003)、坏疽(P=0.019)、Wagner评分(P=0.002)、下肢神经病变(P=0.011)、白介素-6(P=0.012)、白细胞计数(P=0.033)和血沉(P=0.040)更高,而降钙素原2组间差异不明显。结论:降钙素原不能预测糖尿病足溃疡患者的截肢,而白介素-6对糖尿病足溃疡患者截肢有一定的预测价值,需进一步研究证实。Objective：To determine clinical and laboratory factors that predict amputation surgery and to evaluate the predictive value of interleukin-6 （IL-6）, and procalcitonin （PCT） in patients with diabetic foot ulcers （DFUs）. Methods：Forty-ifve DFUs patients admitted to our hospital were consecutively enrolled. The patients’ demographics and wound characteristics were noted. IL-6 and PCT were measured at admission. Re-sults：Twelve of the 45 patients （26.7%） eventually underwent lower extremity amputation. Compared to the non-amputation group, a previous history of amputation （P=0.003）, the presence of gangrene （P=0.019）, the Wagner grade （P=0.002）, the lower extremity neuropathy （P=0.011）, the IL-6 concentration （P=0.012）, the white blood cell count （WBC） （P=0.033）, and the erythrocyte sedimentation rate （ESR） （P=0.040） were signiif-cantly high in the amputation group. However, the PCT concentration was not signiifcantly different. Conclu-sion：PCT failed to predict patients who will eventually require amputation and IL-6 may have predictive value for lower extremity amputation in patients with DFUs. Further studies are needed to conifrm its predictive value in patients with DFUs.

关 键 词：糖尿病足 白介素-6 降钙素原 截肢 INTERLEUKIN-6 

分 类 号：R587.2[医药卫生—内分泌]