HLA-B*5801携带情况及其与别嘌醇过敏反应间的相关性  

HLA-B*5801 carrying station and the correlation of allergic reactions caused by allopurinol

作　　者：叶晓兰[1] 陈朝生[2] 徐仁爱[1] 张春红[1] 潘晓峰[1] 张秀华[1] 

机构地区：[1]温州医科大学附属第一医院药学部,浙江温州325015 [2]温州医科大学附属第一医院肾内科,浙江温州325015

出　　处：《温州医学院学报》2015年第2期143-145,共3页Journal of Wenzhou Medical College

摘　　要：目的:调查我院住院患者HLA-B*5801等位基因携带情况并研究其与别嘌醇发生过敏反应的相关性。方法:收集2013年5月-10月我院住院部100例患者的相关资料,进行汇总分析和检测其HLA-B*5801等位基因。结果:100例患者中,HLA-B*5801等位基因阳性23例,其中有8例患者发生过敏反应。HLA-B*5801阴性者没有发生过敏反应。结论:我院患者携带HLA-B*5801基因概率高,使用别嘌醇前先检测HLA-B*5801可以更安全地用药。Objective：To investigate the HLA-B＊5801 carrying station and it’s correlation of allergic reac-tions caused by allopurinol of our hospitalized patients. Methods：The patients’ data from inpatient department were collected, then their HLA-B＊5801 was analyzed and detected. Results：There were 100 cases determined the HLA-B＊58 allele, and the HLA-B＊5801 allele positive cases were 23, including 8 cases with allergic reac-tion. HLA-B＊5801 negative one did not happen allergic reaction. Conclusion：Our patients carried high rate of HLA-B＊5801, it will be more safe to detect the gene in time before use allopurinol. But the association between HLA-B＊5801 and allergic reaction caused by allopurinol remains further research.

关 键 词：别嘌呤醇 肾功能不全 HLA-B＊5801 过敏反应 

分 类 号：R968[医药卫生—药理学]