多发性骨髓瘤多种磁共振成像序列图像质量的比较  

Comparison of the Quality of Different Magnetic Resonance Image Sequences of Multiple Myeloma

作　　者：孙照勇[1] 张海波[1] 李烁[1] 王沄[1] 薛华丹[1] 金征宇[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院放射科,北京100730

出　　处：《中国医学科学院学报》2015年第1期50-54,共5页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81371608);北京市科技新星项目(Z111107054511127)~~

摘　　要：目的比较磁共振T1WI脂相、T1WI水相、短时反转恢复(STIR)序列以及弥散加权成像(DWI)序列在评价多发性骨髓瘤(MM)时的图像质量。方法对20例初诊或治疗后随诊的MM患者行冠状位T1WI脂相、T1WI水相、STIR序列及轴位DWI序列扫描,分段评价4个扫描序列的图像质量。测量并计算每个扫描序列的颅骨、脊柱、骨盆、肱骨、股骨、胫腓骨及肋骨处图像的信噪比(SNR)。选取20处MM的活动性病灶,测量并计算每个扫描序列病变部位的强化噪声比(CNR)。结果所有图像质量均在可评价范围内。T1WI脂相、T1WI水相、STIR序列以及DWI序列的平均图像质量评分分别为4.19±0.70、4.16±0.73、3.89±0.70及3.76±0.68,T1WI脂相和水相的图像质量明显优于STIR序列(P=0.000和P=0.001)和DWI序列(P均=0.000),但T1WI脂相及水相之间(P=0.723)、STIR序列及DWI序列之间(P=0.167)差异均无统计学意义。T1WI水相的SNR显著高于T1WI脂相、STIR序列及DWI序列(P均=0.000),而后三者间差异无统计学意义(P均>0.05)。DWI序列的CNR均值虽略高于其他3个序列,但4个扫描序列CNR之间差异均无统计学意义(P均>0.05)。结论 T1WI脂相、T1WI水相、STIR序列及DWI序列成像各具优势,应联合应用诊断MM。Objective To compare the image quality of T1 WI fat phase,T1 WI water phase,short time inversion recovery（ STIR） sequence,and diffusion weighted imaging（ DWI） sequence in the evaluation of multiple myeloma（ MM）. Methods Totally 20 MM patients were enrolled in this study. All patients underwent scanning at coronal T1 WI fat phase,coronal T1 WI water phase,coronal STIR sequence,and axial DWI sequence. The image quality of the four different sequences was evaluated. The image was divided into seven sections（ head and neck,chest,abdomen,pelvis,thigh,leg,and foot）,and the signal-to-noise ratio（ SNR）of each section was measured at 7 segments（ skull,spine,pelvis,humerus,femur,tibia and fibula and ribs）were measured. In addition,20 active MM lesions were selected, and the contrast-to-noise ratio（ CNR） ofeach scan sequence was calculated. Results The average image quality scores of T1 WI fat phase,T1 WI water phase,STIR sequence,and DWI sequence were 4. 19 ± 0. 70,4. 16 ± 0. 73,3. 89 ± 0. 70,and 3. 76 ± 0. 68,respectively. The image quality at T1-fat phase and T1-water phase were significantly higher than those at STIR（ P = 0. 000 and P = 0. 001） and DWI sequence（ both P = 0. 000）; however,there was no significant difference between T1-fat and T1-water phase（ P = 0. 723） and between STIR and DWI sequence（ P = 0. 167）.The SNR of T1 WI fat phase was significantly higher than those of the other three sequences（ all P = 0. 000）,and there was no significant difference among the other three sequences（ all P 0. 05）. Although the CNR of DWI sequences was slightly higher than those of the other three sequences,there was no significant difference among all of them（ all P 0. 05）. Conclusion Imaging at T1 WI fat phase,T1 WI water phase,STIR sequence,and DWI sequence has certain advantages,and they should be combined in the diagnosis of MM.

关 键 词：磁共振成像 多发性骨髓瘤 图像质量 短时反转恢复序列 弥散加权成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]