双酚A与女童性早熟的关系  

A study of bisphenol A and precocious puberty in 6-8 years old girls

作　　者：吴海瑛[1] 陈临琪[1] 王凤云[1] 陈秀丽[1] 谢蓉蓉[1] 陈婷[1] 何光照[2] 汪维鹏[2] 

机构地区：[1]苏州大学附属儿童医院,江苏苏州215003 [2]苏州大学药学院,江苏苏州215000

出　　处：《临床儿科杂志》2015年第2期155-159,共5页Journal of Clinical Pediatrics

基　　金：江苏苏州2012科技发展项目(No.SYS201242)

摘　　要：目的探讨双酚A（BPA）与女童性早熟的关系。方法选择2012年8月至12月就诊的103例6-8岁性早熟女童,根据性早熟分类标准分为特发性中枢性性早熟（ICPP）组（n=47）及单纯乳房发育（PT）组（n=56）,选取同期同年龄乳房未发育女童53例为正常对照组。高效液相色谱串联质谱法（HPLC-MS-MS）测定血清BPA,酶联免疫法测定血清Kisspeptin,化学发光法测定血清性激素,比较和分析三组间的差异。结果 ICPP组和PT组的血清BPA检出率高于对照组,ICPP组血清BPA水平高于PT组及对照组,差异有统计学意义（P均〈0.05）;ICPP组血清Kisspeptin水平也高于PT组及对照组,差异有统计学意义（P均〈0.05）;ICPP组血清黄体生成素（LH）峰值及LH/卵泡刺激素（FSH）比值高于PT组,ICPP组及PT组血清雌二醇（E2）水平高于对照组,差异有统计学意义（P均〈0.05）。三组的血清BPA水平与E2、LH峰值及LH/FSH比值有相关性（P〈0.05）,与血清Kisspeptin水平及FSH峰值无相关性（P〉0.05）。结论 BPA与女童ICPP发生有一定的相关性。Objective To study the relationship between bisphenol A and precocious puberty in 6-8 years girls. Methods Atotal of 103 girls aged 6-8 years with precocious puberty in our Endocrine clinic from August to December 2012 were selected. According to the classification standard of precocious puberty, girls are divided into idiopathic central precocious puberty（ICPP） group（n=47） and permature thelarche（PT） group（n=56）, 53 girls with no puberty development were chosen as control group. BPA concentrations were determined with HPLC-MS-MS, sex hormones were determined with chemiluminescence method and Kisspeptin concentrations were determined with ELISA, then the differences among the three groups were compared and the relationships between bisphenol A and sex hormones and Kisspeptin were analyzed. Results The BPA relevance ratio and concentration in ICPP group were higher than those of PT group and control group（P〈0.05）. The peak concentration of LH and LH/FSH in ICPP group were higher than those of PT group（P〈0.05）. The concentration of E2 in ICPP group and PT group were higher than that of control group（P〈0.05）. The concentration of Kisspeptin in ICPP group was higher than that of PT group and control group（P〉0.05）. There were no relationship between the concentrations of bisphenol A and Kisspeptin and FSH peak concentration（P〈0.05）. There were correlations between the concentrations of BPA and E2 and LH peak concentration and LH/FSH（P〈0.05）. Conclusions There is a certain correlation between the concentrations of BPA and ICPP.

关 键 词：双酚A 性早熟 KISSPEPTIN 女童 

分 类 号：R725.8[医药卫生—儿科]