艾司西酞普兰治疗冠心病支架植入术患者伴发焦虑抑郁情绪对照研究  

A control study of escitalopram in anxiety-depression emotion of coronary heart disease patients undergoing stent implantation

作　　者：刘萍[1] 刘俭雄[1] 

机构地区：[1]暨南大学医学院附属珠海医院珠海市人民医院,广东·珠海519000

出　　处：《临床心身疾病杂志》2015年第1期45-47,69,共4页Journal of Clinical Psychosomatic Diseases

摘　　要：目的：探讨放松训练联合草酸艾司西酞普兰对冠心病支架植入术后患者伴发焦虑抑郁情绪的临床疗效和安全性以及对生活质量的影响。方法将65例冠心病冠脉支架植入术后伴焦虑抑郁患者随机分为两组，均予以冠心病常规治疗及放松训练，研究组在此基础上联合草酸艾司西酞普兰治疗，观察8周。采用汉密顿焦虑量表、汉密顿抑郁量表评定焦虑抑郁情绪，生活质量量表评定生活质量，副反应量表评定不良反应。结果治疗后两组汉密顿焦虑量表、汉密顿抑郁量表评分较治疗前显著下降（P＜0．01），研究组较对照组下降更显著（P＜0．01）；研究组生活质量量表的4个领域、对照组1个领域评分较治疗前显著升高（P＜0．01），研究组5个领域评分显著高于对照组（P＜0．01）。治疗过程中两组不良反应均轻微，各项实验室检查均无异常改变。结论放松训练联合草酸艾司西酞普兰能显著改善冠心病冠脉支架植入术患者伴发的焦虑抑郁情绪，提高患者的生活质量，且安全性高，优于单用放松训练治疗。Objective To explore the efficacy and safety of relaxation training plus escitalopram in anxiety‐depression emotion of coronary heart disease （CHD） patients undergoing stent implantation and effect on quality of life .Methods Sixty‐five CHD patients undergoing stent implantation who were accompanied with anxiety‐depression emotion were randomly assigned to two groups ,both groups received CHD routine treatment and relaxation training ,on this basis research group was plus escitalopram oxalate for 8 weeks . Anxiety‐depression emotions were assessed with the Hamilton Anxiety Scale （HAMA） and Hamilton De‐pression Scale（HAMD） ,qualities of life with the Short Form 36 Health Survey Questionnaire （SF‐36） , and adverse reactions with the Treatment Emergent Symptom Scale （TESS） .Results The HAMD and HAMA scores of both groups lowered more significantly after treatment compared with pretreatment （P〈0 .01） ,so did those in research than control group （P〈0 .01）;4 domain scores of the SF‐36 in research group and 1 domain score in control group heightened more significantly after treatment （P〈0 .01） ,so did 5 domain scores in research than control group （P〈0 .01） .Adverse reactions of both groups were mild , all laboratory examinations had no abnormal changes .Conclusion Relaxation training plus escitalopram oxalate could improve the anxiety‐depression emotions of CHD patients undergoing stent implantation and quality of life and has higher safety compared with single relaxation training .

关 键 词：冠心病 支架植入 草酸艾司西酞普兰 放松训练 焦虑 抑郁 汉密顿抑郁量表 汉密顿焦虑量表 生活质量量表 副反应量表 

分 类 号：R541.4[医药卫生—心血管疾病]