血液细胞成分与女性冠状动脉慢血流的关系  

Correlation between blood cell components and slow coronary flow in female patients

作　　者：王苏[1] 张艳艳[2] 张冬花[1] 孙涛[1] 程宇彤[1] 阴赪茜[1] 刘彤[1] 张京梅[1] 李志忠[1] 周玉杰[1] 

机构地区：[1]首都医科大学附属北京安贞医院心内科,北京100029 [2]首都医科大学附属北京安贞医院检验科,北京100029

出　　处：《中华实用诊断与治疗杂志》2015年第2期157-158,161,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(81000130);首都临床特色应用研究(Z131107002213042);基础临床课题(2012JL58)

摘　　要：目的探讨血液细胞成分与女性冠状动脉慢血流(slow coronary flow,SCF)的关系。方法经冠状动脉造影证实冠状动脉狭窄<40%的女性患者169例,根据校正的TIMI血流计帧法分为SCF组95例,对照组74例,比较2组临床血液细胞成分变化。结果 2组年龄、高血压病、2型糖尿病及吸烟史比例比较差异无统计学意义(P>0.05);SCF组前降支动脉、回旋支动脉和右冠状动脉校正的TIMI血流帧数(28.2(23.5,32.9)、34.0(26.0,42.0)、28.0(22.0,34.0))高于对照组(17.6(13.2,20.0)、20.0(16.0,24.0)、18.0(16.0,22.0)帧)(P<0.01),而白细胞计数((5.95(5.21,7.01))×109/L)、中性粒细胞与淋巴细胞比值(1.70(1.35,2.28))、红细胞分布宽度(42.2(40.4,43.8)fL)、血小板平均体积(10.5(9.9,11.1)fL)与对照组((6.09(5.54,7.03))×109/L、2.06(1.45,2.59)、41.6(40.0,43.6)fL、10.5(10.0,11.0)fL)比较差异无统计学意义(P>0.05);SCF组红细胞压积(38.90%(36.70%,41.70%))高于对照组(38.00%(35.60%,40.00%))(P<0.05)。结论红细胞压积是女性冠状动脉SCF的影响因素,高水平红细胞压积可能参与了SCF的病理生理过程。Objective To analyze the correlation between blood cell components and slow coronary flow（SCF）in female patients.Methods A total of 169 female patients with angiographically confirmed stenosis40% were divided into SCF group（n=95）and control group（n=74）according to the corrected TIMI frame count.The clinical variables were compared between two groups.Results There were no significant differences in the age,hypertension,type 2diabetes mellitus and smoking history between two groups（P〉0.05）.The corrected TIMI frame counts of left anterior descending artery,left circumflex coronary artery and right coronary artery were 28.2（23.5,32.9）,34.0（26.0,42.0）and 28.0（22.0,34.0）in SCF group,significantly higher than those in control group（17.6（13.2,20.0）,20.0（16.0,24.0）,18.0（16.0,22.0）（P〈0.01）.There were no significant differences in the levels of white blood cell count,neutrophil to lymphocyte ratio,red blood cell distribution width and mean platelet volume between SCF group（（5.95（5.21,7.01））×10^9/L,1.70（1.35,2.28）,42.2（40.4,43.8）fL,10.5（9.9,11.1）fL）and control group（（6.09（5.54,7.03））×10^9/L,2.06（1.45,2.59）,41.6（40.0,43.6）fL,10.5（10.0,11.0）fL）（P〉0.05）.The hematocrit was higher in SCF group（38.90%（36.70%,41.70%）than that in control group（38.00%（35.60%,40.00%）（P〈0.05）.Conclusion The hematocrit is a risk factor of SCF,which suggests that increased hematocrit may contribute to the pathophysiology of SCF in female patients.

关 键 词：冠状动脉慢血流 红细胞压积 女性 冠状动脉造影 

分 类 号：R543.3[医药卫生—心血管疾病]