高尿酸血症合并糖尿病前期患者血尿酸与高敏C反应蛋白及胰岛素抵抗的关系  

Relationship of serum uric acid with high sensitivity C-reactive protein and insulin resistance in hyperuricaemia patients complicated with prediabetes

作　　者：王立英[1] 马玉霞[1] 董立新[1] 张建军[1] 付卫国[1] 

机构地区：[1]河北省玉田县医院风湿免疫科和肾病科,河北省玉田县064100

出　　处：《中华实用诊断与治疗杂志》2015年第2期171-172,共2页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨高尿酸血症合并糖尿病前期患者血尿酸(serum uric acid,SUA)水平与高敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)、胰岛素抵抗的关系。方法 168例高尿酸血症患者分为2组,112例合并糖尿病前期者为合并组,56例未合并者为未合并组;选择同期40例体检健康者为对照组。检测各组SUA、hs-CRP、空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素(fasting insulin,FINS),计算胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR),并进行组间比较。结果合并组与未合并组hs-CRP((3.95±2.97)、(2.36±1.54)mg/L)、SUA((517.00±40.00)、(475.00±68.00)μmol/L)、FPG((6.65±0.42)、(5.61±0.51)mmol/L)、HOMA-IR(5.10±1.30、3.80±0.90)均高于对照组((0.76±0.51)mg/L、(360.00±41.00)μmol/L、(5.07±0.32)mmol/L、2.50±1.10)(P<0.05);合并组以上指标均高于未合并组,差异有统计学意义(P<0.05)。结论高尿酸血症合并糖尿病前期患者SUA水平与hs-CRP、HOMA-IR、FPG相关。Objective To explore the relationship of serum uric acid（SUA）with high sensitivity C-reactive protein（hsCRP）and insulin resistance in hyperuricaemia patients complicated with prediabetes.Methods A total of 168 patients with hyperuricaemia were divided into complication group complicated with prediabetes（n=112）,and non-complication group not complicated with prediabetes（n=56）.Another 40 health volunteers were as controls（control group）.The SUA,hs-CRP,fasting plasma glucose（FPG）and fasting insulin（FINS）were detected,and homeostasis model assessment of insulin resistance（HOMA-IR）was calculated and compared among groups.Results The levels of hs-CRP,SUA,FPG and HOMA-IR were the highest in complication group（（3.95±2.97）mg/L,（517.00±40.00）μmol/L,（6.65±0.42）mmol/L,5.10±1.30）,followed by non-complication group（（2.36±1.54）mg/L,（475.00±68.00）μmol/L,（5.61±0.51）mmol/L,3.80±0.90）and control group（（0.76±0.51）mg/L,（360.00±41.00）μmol/L,（5.07±0.32mmol/L,2.50±1.10）in turns（P〈0.05）.Conclusion SUA level is correlated with hs-CRP,HOMA-IR and FPG in hyperuricemia patients complicated with prediabetes.

关 键 词：高尿酸血症 糖尿病前期 超敏C反应蛋白 血糖 胰岛素抵抗 

分 类 号：R589.7[医药卫生—内分泌] R587.1[医药卫生—内科学]