布地奈德福莫特罗粉吸入剂治疗青少年变应性鼻炎合并哮喘患者的一氧化氮呼出气变化  

Change of Nitric Oxide in the Exhaled Gas of Teenager Patients with Allergic Rhinitis Accompanied with Asthma Treated by Budesonide Formoterol Inhalant

作　　者：刘桂桃[1,2] 陶颖[1] 王茜[3] 魏燕华[2] 聂利平 尹万斌[2] 武艳品 王小华[2] 蔚文龙 

机构地区：[1]新疆医科大学第五附属医院职业病防治科,乌鲁木齐830011 [2]新疆医科大学临床医学院,乌鲁木齐830011 [3]新疆医科大学公共卫生学院,乌鲁木齐830011

出　　处：《华西医学》2015年第2期246-249,共4页West China Medical Journal

基　　金：国家自然科学基金(81360416);新疆医科大学科研创新基金(XJC2011110)~~

摘　　要：目的观察布地奈德福莫特罗粉吸入剂治疗青少年变应性鼻炎合并哮喘的疗效。方法选取2012年1月-2013年12月45例青少年变应性鼻炎合并哮喘患者,完全随机化分组分成一般治疗组、布地奈德组、布地奈德福莫特罗组,每组15例,另设体检健康者15例为对照组。一般治疗组采用氨茶碱等一般治疗,布地奈德组在一般治疗基础上,给予布地奈德气雾剂100~200μg/（吸·次）,2次/d;布地奈德福莫特罗组为一般治疗＋布地奈德福莫特罗粉吸入剂,1吸/次,2次/d,其中吸入剂中含布地奈德含量160μg,福莫特罗4.5μg。连续用药4周后,停药4周进行一氧化氮（NO）呼出气检查。结果一般治疗组、布地奈德组、布地奈德福莫特罗组NO呼出气治疗前后自身相比,差异有统计学意义（P〈0.05）;3组治疗前后与对照组比较差异均有统计学意义（P〈0.05）;布地奈德组、布地奈德福莫特罗组NO呼出气治疗后相比差异有统计学意义（P〈0.05）。结论布地奈德福莫特罗吸入剂治疗青少年变应性鼻炎合并哮喘患者在改善NO呼出气方面效果良好。Objective To observe the effect of Budesonide formoterol inhalant on teenager patients with allergic rhinitis accompanied with asthma. Methods Forty-five teenager patients with allergic rhinitis accompanied with asthma treated between January 2012 and December 2013 were randomly divided into general treatment group, budesonide group and budesonide formoterol group, with 15 patients in each. Another 15 subjects undergoing physical examination were designated as the control group. Besides routine treatment, the budesonide group was also treated with budesonide inhalation at 100-200 μg twice a day, and the budesonide formoterol group was also treated with budesonide formoterol inhalation at 160 μg and 4.5 μg twice a day. The course of treatment lasted for four weeks. The patients were followed up for four weeks after the use of medicine halted. After treatment, exhaled nitric oxide （NO） examination were performed. Results The amount of NO in the exhaled gas in all the three treatment groups were significantly different from the control group （P 〈 0.05）, and it was also significantly different between the Budesonide group and the budesonide formoterol group （P 〈 0.05）. Conclusion Budesonide formoterol inhalant has a good effect on teenager patients with allergic rhinitis accompanied with asthma in terms of improving exhaled NO.

关 键 词：布地奈德福莫特罗吸入剂 变应性鼻炎 支气管哮喘 呼出气一氧化氮 

分 类 号：R562.25[医药卫生—呼吸系统]