miR-126与血管的研究进展  

The research progress of miR-126 and blood vessels

作　　者：李云[1,2] 宋银宏[1] 吕云波[2] 

机构地区：[1]三峡大学医学院免疫学教研室 [2]三峡大学人民医院心内科,湖北宜昌443000

出　　处：《基础医学与临床》2015年第2期257-261,共5页Basic and Clinical Medicine

基　　金：三峡大学自然科学基金(KJ2013A012)

摘　　要：MicroRNAs(miRNAs)是一类高度保守的内源性非编码小分子单链RNA,它能通过非特异性识别靶基因mRNA,在翻译水平调节基因表达,从而调节细胞的多种生物功能。目前已发现多种miRNA,其中miR-126主要存在于血管内皮细胞及血小板中,与血管的生成、发育、修复功能密切相关,可以作为研究冠心病及其他血管性疾病的良好突破口。MicroRNAs（ miRNAs） is one kind of highly conservative endogenous non-coding single-stranded RNAs with small molecule,it is able to regulate gene expression at the translation level by non-specific identification of target genes＇ mRNA,and it can regulate various biological functions of cells. Up to now a variety of microRNAs have been found,in which miR-126 mainly exists in vascular endothelial cells and platelets,and is closely related to the generation,development and repairing of blood vessels. Therefore,miR-126 will become a very good breach to study coronary heart disease and other vascular diseases.

关 键 词：MIR-126 血管 血管内皮生长因子 血管细胞黏附分子-1 

分 类 号：R346[医药卫生—基础医学]