黄芪 水蛭对实验性脑缺血大鼠的改善作用研究  

Effect of Astragalus membranaceus and leech on experimental cerebral ischemia of rats

作　　者：钟菊迎[1] 刘钊[1] 李晶哲[1] 马琰岩[1] 高尔宁 杨鸿[1] 

机构地区：[1]中国中医科学院医学实验中心,北京100700

出　　处：《山西医药杂志》2015年第4期380-382,共3页Shanxi Medical Journal

基　　金：中国中医科学院自主课题(Z2012012)

摘　　要：目的观察黄芪、水蛭对大鼠局灶性脑缺血引起的脑梗死的保护作用。方法大鼠按体质量均匀分为假手术对照组、模型对照组、黄芪、水蛭(9∶1,7∶1,5∶1)剂量组,预给药4d后采用线栓阻断大脑中动脉血供造成大鼠局灶性脑缺血模型(MCAO),观察黄芪、水蛭对脑缺血大鼠脑梗死比例以及凝血酶原时间(PT)的影响。结果与模型对照组比较,黄芪、水蛭组可不同程度降低局灶性脑缺血大鼠脑梗死面积(P<0.01,P<0.05),并能明显延长PT时间。结论黄芪、水蛭可明显降低大鼠脑缺血梗死率。Objective To observe the neuroprotection effect of Astragalus membranaceus and leech on cere‐bral infarction caused by acute cerebral ischemia in rats .Methods Cerebral ischemia and infarction in rats were in‐duced by middle cerebral artery occlusion（MCAO） .The effects of Astragalus membranaceus and leech were evalu‐ated in the three models .The different doses of Astragalus membranaceus and leech were administrated before modeling（9∶1 ,7∶1 ,5∶1）.Astragalus membranaceus and leech was given for 4 days before modeling.Results Each dose group of Astragalus membranaceus and leech could significantly reduce infarction ratio of cerebral ische‐mia（ P〈 0 .05 ,P 〈0 .01）and significantly prolong prothrombin time in rats .Conclusion Astragalus membrana‐ceus and leech has good pharmacological effects on cerebral ischemia in rats.

关 键 词：黄芪 水蛭 脑缺血 中风 模型 动物 

分 类 号：R285.5[医药卫生—中药学]