氨氯地平与缬沙坦分别联合氢氯噻嗪对控制原发性高血压血压的系统评价  

Effect of mlodipine/hydrochlorothiazide in patients with essential hypertension:A systematic review

作　　者：罗天勇[1] 李一梅[1] 谢波[1] 韩琳娜[1] 江莲[1] 胡乾配 李琼[1] 

机构地区：[1]重庆医科大学附属永川医院全科医学科,402160

出　　处：《重庆医学》2015年第5期673-675,共3页Chongqing medicine

摘　　要：目的采用系统评价方法,确定氨氯地平联合氢氯噻嗪(A/H)与缬沙坦联合氢氯噻嗪(V/H)比较,治疗原发性高血压的降压效果及安全性。方法计算机检索Cochrane Library、PubMed、OVID、MEDLINE、EMBASE、CBM、CNKI、VIP、万方等数据库,检索时间为建库至2013年11月;手工检索相关杂志纸质版。对纳入文献进行方法学质量评价,用RevMan 5.2软件进行统计分析。结果共纳入7篇随机对照试验。Meta分析结果显示:在降低动态血压方面,V/H优于A/H,差异有统计学意义(P<0.05);在降低诊室血压及血压控制率方面,V/H与A/H差异无统计学意义(P>0.05)。与A/H相比,V/H出现不良反应的可能性更小,差异有统计学意义(P<0.05)。结论 A/H治疗原发性高血压对血压的改善不如V/H,且不良反应发生更多。Objective To systematically evaluate the efficacy and safety of amlodipine（A）/hydrochlorothiazide（H）versus valsartan（V）/hydrochlorothiazide（H）in treatment of essential hypertension.Methods Literature was retrieved online in Cochrane Library,PubMed,OVID,MEDLINE,EMBASE,CBM,CNKI,VIP and Wan fang database up to November 2013.Relevant magazines were retrieved manually.Quality of the included studies was assessed and Meta-analysis was performed with RevMan 5.2software.Results Seven randomized controlled trials（RCTs）were finally included.Meta-analyses showed that：in terms of lowering ABP,V/H group was more effective than A/H group,the difference was statistically significant（P〈0.05）;there was no significant difference in the decreased value of clinic BP and the control rate of blood pressure between A/H group and V/H group（P〉0.05）.Adverse events occurred less frequently with V/H group compared with A/H group,the difference was statistically significant（P〈0.05）.Conclusion A/H treatment of essential hypertension is inferior to V/H,and has more adverse events.

关 键 词：氨氯地平 缬沙坦 氢氯噻嗪 原发性高血压 系统评价 

分 类 号：R544.1[医药卫生—心血管疾病]