冠心宁注射液治疗冠心病心绞痛有效性及安全性的Meta分析  

A Meta analysis of Guanxinning Injection Treating Patients with Unstable Angina

作　　者：高长春[1] 林淑梅[1] 徐国良[1] 秦玲[1] 

机构地区：[1]吉林大学第一医院,吉林长春130031

出　　处：《中国中医急症》2015年第2期238-241,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：吉林省科技厅科研项目(200905138)

摘　　要：目的用Meta分析的方法来研究冠心宁注射液治疗冠心病心绞痛的疗效及其安全性。方法通过应用电子计算机对Cochrane图书馆临床对照试验资料库(2014年第2期)、中国学术文献(CNKI)总库(1979年至2014年6月)、万方数字化期刊库(1981年至2014年6月)、中文科技期刊数据库(1989年至2014年6月),Pubmed(1966年2014年6月)、Embase(1966年至2014年6月)进行检索,对临床随机对照试验按照一定的入选标准和排除标准进行选择,对文献的质量进行评价,从中找到所需要的数据,应用软件Rev Man 5.3对提取的数据来进行Meta分析。结果经过初步检索,有581篇文献入选,按照入选标准和排除标准最终18篇关于冠心宁注射液治疗冠心病心绞痛的随机对照研究入选。应用心绞痛缓解作为标准:χ2=6.70,df=17,P=0.99,合并OR=4.13,95%CI[3.10,5.50],Z=9.70(P<0.00001)。应用心电图改善作为标准:χ2=9.71,df=17,P=0.92,合并OR=3.22,95%CI[2.58,4.02],Z=10.31(P<0.00001)。各试验组均未发现严重的不良反应。结论冠心宁注射液治疗冠心病心绞痛缓解心绞病症状及改善心电图都是有效的,且临床应用安全。0bjective： To study the efficacy and safety of Guanxinning injection in treating patients with unstable angina（UA）. Methods： We searched the Cochrane Central Register of Controlled Trials（Issue2,2014）,CNKI（1979 to June 2014）,Wanfang Data（1981 to June 2014）,CSTJ（1981 to June 2014）,Pubmed（1966 to June2014）,and EMbase（1966 to June 2014）.Randomized controlled trials（RCTs） in which Guanxinning Injection was used to treating patients with UA were collected.Then we screened the retrieved studies according to predefined inclusion and exclusion criteria,evaluated the quality of included studies,and performed meta analyses by using Rev Man 5.3 software.Therapeutic effects of angina pectoris and efficacy of electrocardiogram（ECG） were selected as the study indices. Results： A total of 581 articles were found and 18 of which were finally included.Therapeutic effects of angina pectoris were selected as the study indices：χ2=6.70,df=17,P = 0.99,OR=4.13,95%CI [3.10,5.50],and Z=9.70（P 〈0.00001）. ECG was selected as the study indices：χ2=9.71,df=17,P = 0.92,OR=3.22,95%CI [2.58,4.02],and Z=10.31（P 〈0.00001）. Conclusion： Guanxinning injection is effective in treating patients with unstable angina and improving ECG,Which is safe for application.

关 键 词：冠心宁注射液 冠心病 心绞痛 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]