三组分[3+2+1]杂环化合成1,3,5-三嗪衍生物  

Three-component[3+2+1]heteroannulation for the synthesis of 1,3,5-triazine derivatives

作　　者：童华绒 韩军文[1] 王丹[1] 董吉[1] 李小凡[1] 施吉祥[1] 姜波[1] 

机构地区：[1]江苏师范大学化学化工学院,江苏徐州221116

出　　处：《江苏师范大学学报（自然科学版）》2015年第1期70-73,共4页Journal of Jiangsu Normal University：Natural Science Edition

基　　金：国家自然科学基金资助项目(21232004)

摘　　要：在微波辐射下,以乙二醇为溶剂,碳酸铯为碱促进剂,将芳甲脒和醛以物质的量之比2∶1反应,合成了一系列1,3,5-三嗪衍生物.该方法具有反应时间短（22～30min）、操作简单和环境友好等优点.产物经红外光谱、核磁共振氢谱、质谱表征,2-对甲苯基-4,6-二苯基-1,3,5-三嗪的结构经单晶X射线衍射分析予以确证.Using ethane-1,2-diol as solvent and Cs2CO3 as base promoter,a series of 1,3,5-triazine derivatives were synthesized via a three-component reaction of aryl carboximidamide and aldehydes with the the ratio of amount of substance 2∶1under microwave irradiation.This method has the advantages of short reaction times（22～30min）,simple operation and environment friendliness.The structures of the products were identified by IR,1 HNMR and HRMS.Furthermore,the compound 2-（4-methylphenyl）-4,6-diphenyl-1,3,5-triazine was confirmed by X-ray diffraction.

关 键 词：微波辐射 1 3 5-三嗪衍生物 [3+2+1]杂环化 三组分反应 

分 类 号：O625[理学—有机化学]