甘草甘遂不同配伍比例对大鼠肾功能的影响  

EFFECTS OF EUPHORBIA KANSUI LICORICE IN DIFFERENT COMPATIBILITY PROPORTION ON RATS' RENAL FUNCTION

作　　者：孙逸雨 张腾[2] 杨霄[2] 佟继铭[2] 张树峰[2] 

机构地区：[1]河北联合大学中医学院,河北唐山063000 [2]承德医学院

出　　处：《承德医学院学报》2015年第1期8-10,共3页Journal of Chengde Medical University

摘　　要：目的:观察长期灌胃甘草甘遂不同配伍比例水煎剂对大鼠肾功能的影响。方法:50只SD大鼠随机分为正常对照组,甘遂组,甘遂配伍甘草1:0.25组、1:0.5组和1:1组,每组10只大鼠,各组大鼠均连续灌胃给药28天。检测大鼠血肌酐(Cr)和尿素氮(BUN)的含量,HE染色观察肾脏形态结构的变化。结果:各用药组大鼠血Cr和BUN的含量明显高于正常对照组大鼠,以甘遂组最为显著(P<0.01,P<0.05);甘遂甘草配伍组,随甘草比例的增加,大鼠血Cr和BUN的含量逐渐降低(P<0.01,P<0.05)。各用药组大鼠肾脏形态结构均发生不同程度的病理变化,以甘遂组最为严重;甘遂甘草配伍组,随甘草比例的增加,肾脏的病理变化逐渐减轻。结论:长期使用甘遂对大鼠肾脏具有明显的毒性作用,甘草与甘遂配伍具有减轻甘遂对肾脏毒性作用的功效,且与甘草的比例有关。Objective：To observe the effects of long-term gastric perfusion with water decoction of euphorbia kansui licorice in different compatibility proportion on rats＇ renal function.Methods：50 SD rats were randomly divided into 5 groups with 10 rats in each group： normal control group, euphorbia kansui group, euphorbia kansui licorice 1：0.25, 1：0.5 and 1：1 groups. The rats were all lavaged with corresponding drugs for 28 days. The creatinine（Cr） and urea nitrogen（BUN） content in blood of rats were respectively detected. HE stain was used to observe the pathological changes of kidney.Results： The Cr and BUN content in blood of rats in each drug group were all obviously higher than that of rats in normal control group, especially the euphorbia kansui group（P〈0.01, P〈0.05）. For compatibility groups, the Cr and BUN content in blood gradually decreased with increasing of the proportion of licorice（P〈0.01, P〈0.05）. The morphology of kidney of rats in each drug group appeared pathological changes in different degree, especially the euphorbia kansui group. For compatibility groups, the pathological changes of kidney gradually reduced with increasing of the proportion of licorice. Conclusions： It has obvious toxic effects on kidney after long-term using of euphorbia kansui. Compatibility of licorice and euphorbia kansui can reduce the toxic effects of euphorbia kansui on kidney; moreover, this efficiency is associated with the proportion of licorice.

关 键 词：甘遂 甘草 肾脏 肌酐 尿素氮 

分 类 号：R965[医药卫生—药理学]