IL-23R基因单核苷酸多态性与肝癌预后的关系  

Association between single nucleotide polymorphism of IL-23R gene and prognosis of hepatocellular carcinoma

作　　者：覃彦平 曹昭[2] 覃锦耀[2] 林观凤 吴君荣[2] 

机构地区：[1]广西柳州市红十字会医院检验科,广西柳州545001 [2]广西医科大学第一附属医院检验科,广西南宁530021 [3]广西柳州市红十字会医院放射科,广西柳州545001

出　　处：《右江民族医学院学报》2015年第1期20-22,共3页Journal of Youjiang Medical University for Nationalities

基　　金：广西壮族自治区卫生厅自筹经费科研课题(Z2012548)

摘　　要：目的探讨IL-23R基因单核苷酸多态性与肝癌手术治疗患者预后的关系。方法采用PCR-限制性片段长度多态性(PCR-RFLP)法检测68例肝癌患者IL-23R基因rs17375018及rs11805303位点单核苷酸多态性基因型并分析其与预后的关系。结果这两个位点在年龄、病理分级、复发及存活与否分组中的基因型分布频率比较差异均无统计学意义(P>0.05);在性别分组间rs17375018位点多态性分布频率比较差异无统计学意义(P>0.05),rs11805303位点性别分组间比较差异有统计学意义(P<0.05),其男、女性患者高比例基因型分别为:CT型、CC型。结论 IL-23R基因单核苷酸多态性可能与肝癌术后患者生存状况无关。Objective To study the relationship between the single nucleotide polymorphism of IL-23 R gene and post-operative prognosis of hepatocellular carcinoma. Methods PCR-restriction fragment length polymorphism（PCR-RFLP）method was applied to determine the genotypes of IL-23Rgene（rs17375018and rs11805303loci）in 68 patients with hepatocellular carcinoma and the relationship between the genotypes and prognosis of the patients were analyzed. Results There were no statistically differences in comparison of genotype frequency distribution of the two gene loci at different age,different pathological grading,with or without recurrence and survival or not groups（P〉0.05）;there were also no significant differences in the distribution frequency of rs17375018 loci between sex groups（P〉0.05）,but the comparison of distribution frequency of rs11805303 site yielded significant differences between sex groups（P〈0.05）.The high proportion of gene type in male and female patients were CT type and CC type,respectively. Conclusion The single nucleotide polymorphism of IL-23 Rgene may have no association with the postoperative life quality of hepatocellular carcinoma.

关 键 词：白细胞介素-23受体 肝肿瘤 术后复发 生存率 

分 类 号：R392.12[医药卫生—免疫学]