参芎注射液对腹膜透析患者转化生长因子β1的影响  

Effect of shenxiong injection on TGFβ1 in patients undergoing peritoneal dialysis

作　　者：寿苗林[1] 李素波[1] 张小云[1] 

机构地区：[1]杭州市萧山区第一人民医院肾内科,杭州311201

出　　处：《实用药物与临床》2015年第2期135-137,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的观察参芎注射液对腹膜透析患者转化生长因子β1(TGFβ1)及腹膜功能的影响。方法选择2012年12月至2014年5月我院肾内科进行腹膜透析的60例患者,随机分为2组:常规腹膜透析组(对照组)和参芎注射液腹膜透析组(观察组),每组30例。比较两组相关临床和生化指标,应用ELISA法检测TGFβ1表达。结果治疗前,两组肌酐透析液与血浓度之比(D/Pcr)、尿素清除指数(KT/V)、肌酐清除率(Ccr)、尿量和超滤量比较差异无统计学意义(P>0.05)。治疗后,对照组上述指标无显著变化(P>0.05);观察组D/Pcr、KT/V、Ccr、尿量与治疗前比较差异无统计学意义(P>0.05),但超滤量升高(P<0.01)。两组血浆白蛋白(ALB)、钙(Ca)、磷(P)、甲状旁腺素(iP TH)在治疗前、后比较差异均无统计学意义(P>0.05)。治疗前,两组TGFβ1表达水平比较差异无统计学意义(P>0.05);治疗后,对照组TGFβ1表达无显著变化(P>0.05),但观察组显著减低(P<0.01)。结论参芎注射液可显著提高腹透患者的超滤量,抑制腹膜细胞的TGFβ1分泌,具有抗腹膜纤维化的功效。Objective To observe the effect of shenxiong injection on TGFβ1 in patients undergoing peritoneal dialysis（ PD）. Methods 60 cases of PD patients were divided into control group（ conventional peritoneal dialysis group,n = 30） and observation group（ shenxiong injection group,n = 30）. The clinical and biochemical indicator were compared between the two groups. TGFβ1 was detected by ELISA analysis. Results Before treatment,there was no significant difference in D / Pcr,KT / V,Ccr,urine volume and ultrafiltration volume between the two groups（ P 〉0. 05）. After treatment,the ultrafiltration volume of observation increased（ P 〈 0. 01）,and no change was found of the other indexes in the two groups（ P 〉 0. 05）. No significant difference was found in ALB,Ca,P,and iP TH between the two groups before and after treatment（ P 〉 0. 05）. Before treatment,no significant difference was observed in TGFβ1between the two groups（ P 〉 0. 05）; After treatment,no change was found in control group（ P 〉 0. 05）,while TGFβ1in observation group significantly decreased（ P 〈 0. 01）. Conclusion Shenxiong injection could significantly improve the ultrafiltration volume in PD,and inhibit the TGFβ1 expression to resist peritoneal fibrosis.

关 键 词：参芎注射液 腹膜透析 转化生长因子Β1 

分 类 号：R285.6[医药卫生—中药学]