夜间阴茎勃起功能监测结果与代谢综合征的相关性研究  

Correlation between metabolic syndrome and nocturnal penile tumescence test results

作　　者：肖飞[1] 闫志安[1] 谷现恩[1] 

机构地区：[1]北京市垂杨柳医院泌尿外科,100022

出　　处：《中华泌尿外科杂志》2015年第2期144-147,共4页Chinese Journal of Urology

摘　　要：目的 探讨夜间阴茎勃起功能（nocturnal penile tumescence,NPT）监测结果与代谢综合征（metabolic syndrome,MS）的相关性. 方法 本前瞻性研究从2010年6月至2011年6月入组25例健康志愿者设为A组（健康对照组）,入组25例NPT正常的勃起功能障碍（erectile dysfunction,ED）患者设为B组（NPT正常ED组）,入组25例NPT异常的ED患者设为C组（NPT异常ED组）.入组时3组受试者血清总睾酮均＞9.9 nmol/L,并排除MS诊断.入组时3组受试者腰围、体质指数、空腹血糖、平均动脉压、三酰甘油、高密度脂蛋白、总胆固醇及血清总睾酮组间两两比较差异均无统计学意义（P＞0.05）,B、C两组国际勃起功能评分差异无统计学意义（P＞0.05）.3年后随访,再次检测以上代谢数据,并比较3组受试者MS的发生率. 结果 3年后随访时,失访者A组2例,B组3例,C组5例.A、B两组各项指标比较差异无统计学意义（P＞0.05）;A、C两组比较,平均动脉压、空腹血糖、高密度脂蛋白、总胆固醇差异有统计学意义（P＜0.05）;B、C两组比较,平均动脉压、高密度脂蛋白差异有统计学意义（P＜0.05）.3年后A组患MS者2例,B组3例,C组7例,3组间MS发病率差异有统计学意义（P＜0.05）. 结论 NPT结果能在一定程度上反映和预测MS的发生和发展,可作为早期预警MS的参考指标之一,值得注意.Objective To investigate the correlation between nocturnal penile tumescence （NPT） test results and metabolic syndrome （MS）.Methods In this prospective study,75 cases were enrolled,including 25 healthy volunteers （group A）,25 erectile dysfunction （ED） patients with normal NPT results （group B）,and 25 ED patients with abnormal NPT results （group C）.At the time of recruitment,all the participants had serum total testosterone higher than 9.9 nmol/L,and were free of MS.At baseline,there was no significant differences in waistline,body mass index,fasting plasma glucose （FPG）,mean arterial pressure （MAP）,triglyceride,high density lipoprotein （HDL）,cholesterol,and serum total testosterone among the three groups （P〉0.05）.And there was no significant difference in international index of erectile function 5 score between group B and C.A follow-up survey was conducted three years after baseline to measure the above metabolic indicators and to compare the incidence of MS among the three groups.Results In the three-year follow-up survey,2 participants in group A were lost to follow-up,compared to 3 participants in group B and 5 participants in group C.In the three-year follow-up survey,there was no significant difference in all the indicators between group A and B; between group A and C,significant differences were observed in MAP,FPG,HDL,and cholesterol （P〈0.05）; between group B and C,significant differences were observed in MAP and HDL （P〈0.05）.In the three-year follow-up survey,2 participants in group A developed MS,compared to 3 MS patients in group B and 7 MS patients in group C.There was a significant difference in the incidence of MS among the three groups （P〈0.05）.Conclusions To some extent,NPT reflects and predicts the development and progress of MS.Therefore,NPT can be used as an early indicator of MS.

关 键 词：勃起功能障碍 夜间阴茎勃起功能监测 代谢综合征 前瞻性研究 

分 类 号：R589[医药卫生—内分泌] R697.14[医药卫生—内科学]