38例银杏达莫注射液不良反应报告分析  

Analysis of 38 Cases of Adverse Drug Reactions Induced by Ginkgo Leaf Extract and Dipyridamole Injection

作　　者：丁月霞[1] 张雷[1] 刘飞宇[1] 赵莉[1] 孙海燕[1] 张华芸[1] 赵泉[1] 

机构地区：[1]烟台毓璜顶医院药学部,山东烟台264000

出　　处：《药物流行病学杂志》2015年第2期114-116,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的：分析我院银杏达莫注射液不良反应（adverse drug reaction,ADR）发生的特点,探讨其影响因素,为临床合理用药提供参考。方法：从国家药品不良反应监测系统中收集我院2008～2013年银杏达莫注射液ADR报告,对患者年龄及性别分布、新的/严重的比例、联合用药、ADR累及器官、临床表现、ADR结果及关联性评价进行描述性分析。结果：6年间我院上报的银杏达莫注射液ADR共38例,其中严重ADR 4例;78.95%用药符合药品说明书中的适应证,21.05%超说明书用药;其中42.11%的患者单次用量超过说明书推荐的剂量;97.37%的患者溶媒量使用不足;5.26%的患者联合使用其他药物。结论：超适应证用药、联合用药、用量不适宜、溶媒选择不适宜是导致银杏达莫注射液ADR发生的原因。使用银杏达莫注射液要严格掌握适应证,按照说明书推荐的用法用量与溶媒使用,不与其他药品混合配伍使用,以减少和避免ADR的发生,保障患者用药安全。Objective： To analyze the characteristics of adverse reactions caused by Ginkgo leaf extract and dipyridamole injection,and explore the factors related to this phenomenon in order to provide the reference to clinical rational drug use. Methods： The data of Ginkgo leaf extract and dipyridamole injection adverse reactions in our hospital were collected from the National Adverse Drug Reaction Monitoring System from 2008 to 2013. A descriptive analysis was made on distribution of patients＇ age / sex,proportions of new / serious cases,the combination medication,organs entailed by ADR,clinical manifestations,ADR results and relevance evaluation. Results： There were 38 cases of adverse drug reactions induced by Ginkgo leaf extract and dipyridamole injection from 2008 to 2013 in our hospital,of which 4 cases were serious;78. 95% was in accordance with the drug instructions; 21. 05% was not conformed to the instructions of the indications.Moreover,42. 11% of the patients with single amount exceeded the specifications recommended dosage; 97. 37% of the patients were insufficient solvent,5. 26% of the patients combined with other drugs. Conclusion： Not conforming to the instructions of the indications,the combination of medication,incorrect dosage and insufficient solvent contributed to the adverse reactions caused by Ginkgo leaf extract and dipyridamole injection. Ginkgo leaf extract and dipyridamole injection should be used according to the instructions to prevent the occurrence of ADR and improve rational drug levels.

关 键 词：银杏达莫注射液 药品不良反应 合理用药 

分 类 号：R286[医药卫生—中药学]