功能性消化不良亚型与中医辨证及GLP-1水平的关系  

The relationship between the subtypes of functional dyspepsia and TCM differentiation and the level of GLP-1

作　　者：王滢滢[1] 李晶[2] 张凤宾[1] 张瑞星[1] 

机构地区：[1]河北医科大学第四医院消化内科,河北石家庄050011 [2]河北医科大学第四医院中医科,河北石家庄050011

出　　处：《中国中西医结合消化杂志》2015年第2期112-114,117,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：河北省中医药管理局课题(No:2011077)

摘　　要：[目的]观察不同亚型功能性消化不良(FD)患者与中医证型和胰高血糖素样肽-1(GLP-1)水平的关系,探讨FD的发病机制和传统医学在FD诊治中的作用。[方法]83例FD患者,按罗马Ⅲ标准分为上腹痛综合征(EPS)和餐后不适综合征(PDS)2组,分别进行中医辨证及测定血清GLP-1水平。[结果]EPS组脾胃虚寒证占48.0%,其次为脾胃湿热证与肝胃不和证。PDS组肝胃不和证占51.7%,其次为脾胃湿热证与脾胃虚寒证。EPS组与PDS组GLP-1水平分别为(4.04±0.42)pmol·L-1和(3.62±0.35)pmol·L-1。[结论]1EPS亚型以脾胃虚寒证为主,PDS亚型以肝胃不和证为主。2GLP-1对FD患者不同症状的发生影响不大。[Objective]To observe the relationship between different syndrome types in Traditional Chinese Medicine（TCM）and subtypes of functional dyspepsia（FD）,and to explore the effect of glucagon-like peptide-1（GLP-1）on the pathogenesis of FD.[Methods]According to Rome Ⅲ criteria,83 patients diagnosed as FD were enrolled and divided into two groups：Epigastric Pain Syndrome（EPS）,and Postprandial Distress Syndrome（PDS）.TCM syndrome differentiation of FD patients was classified by the same experienced TCM doctor and the levels of GLP-1were detected by enzyme linked immunosolid assay（ELISA）method.[Results]There were 25 in EPS and 58 in PDS in all the patients.The insufficiency of spleen-Yang syndrome was the most in EPS,a total of 12cases（48.0%）,followed by the dampness-heat in spleen and stomach syndrome and the hepatogastric discord syndrome.The hepatogastric discord syndrome was the most in PDS,30cases（51.7%）,followed by the dampness-heat in spleen and stomach syndrome and the insufficiency of spleen-Yang syndrome.The levels of GLP-1in EPS and PDS were（4.04±0.42）pmol·L^-1 and（3.62±0.35）pmol·L^-1 respectively.There was no significant difference between the GLP-1levels of the two subtypes of FD patients.[Conclusion]1The insufficiency of spleen-Yang syndrome was the main syndrome in EPS,and the hepatogastric discord syndrome was the main in PDS.2There was less effect of GLP-1on pathogenesis of the two subtypes of FD.

关 键 词：功能性消化不良 上腹痛综合征 餐后不适综合征 中医辨证 胰高血糖素样肽-1 

分 类 号：R256.3[医药卫生—中医内科学]