维生素D治疗对2型糖尿病合并呼吸道感染患者细胞免疫功能的影响研究  

Influence of Vitamin D Therapy on Cellular Immune Function of Type 2 Diabetes Mellitus Patients Complicated with Respiratory Tract Infection

作　　者：么焕新 柴颖[2] 张永敬[1] 

机构地区：[1]河北省唐山市协和医院老年病科,063000 [2]唐山市职业技术学院护理系

出　　处：《实用心脑肺血管病杂志》2015年第1期30-32,36,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：2012年唐山市科技局计划指导项目(121302126a)

摘　　要：目的探讨维生素D治疗对2型糖尿病合并呼吸道感染患者细胞免疫功能的影响。方法选取唐山市协和医院2013年1—3月收治的2型糖尿病合并呼吸道感染患者60例,随机分为对照组和观察组,每组30例。对照组患者在常规治疗基础上给予安慰剂,观察组患者在常规治疗基础上给予骨化三醇胶丸;两组患者均连续治疗4周。观察两组患者治疗前后骨代谢指标(血清钙、磷、碱性磷酸酶、25羟维生素D3水平)和细胞免疫指标(CD+3、CD+4、CD+8细胞分数及CD+4/CD+8比值)变化。结果两组患者治疗前血清钙、磷、碱性磷酸酶、25羟维生素D3水平及治疗后血清磷、碱性磷酸酶水平比较,差异均无统计学意义(P>0.05);观察组患者治疗后血清钙、25羟维生素D3水平高于对照组(P<0.05)。两组患者治疗前CD+3、CD+4、CD+8细胞分数及CD+4/CD+8比值和治疗后CD+4、CD+8细胞分数比较,差异均无统计学意义(P>0.05);观察组患者治疗后CD+3细胞分数及CD+4/CD+8比值高于对照组(P<0.05)。结论维生素D治疗可增强2型糖尿病合并呼吸道感染患者细胞免疫功能,且安全性较高。Objective To investigate the influence of vitamin D therapy on cellular immune function of type 2 diabetes mellitus patients eomplicated with respiratory tract infection. Methods A total of 60 type 2 diabetes mellitus patients complicated with respiratory tract infection were selected in Xiehe Hospital of Tangshan from January to March in 2013, and they were randomly divided into control group and observation group, each of 30 cases. Both groups given routine treatment, and control group given extra placebo, while observation group given extra calcitriol soft capsules; both groups treated for 4 weeks. Before and after treatment, bone metabolic markers including serum levels of calcium, phosphorus, alkaline phosphatase and 25 hydroxy vitamin D3, index of cellular immunity including CD3＋ , CD4, CD~ percentage and CD4＋/CD8＋ ratio were compared between the two groups. Results No significant differences of bone metabolic markers including serum levels of calcium, phosphorus, alkaline phosphatase and 25 hydroxy vitamin D3 or index of cellular immunity including CD3＋ , CD4＋ , CD8＋ percentage and CD4/CD8＋ ratio was found between the two groups before treatment （ P 〉 0. 05 ） ; after treatment, serum levels of calcium and 25 hydroxy vitamin D3, CD3＋ percentage and CD4/CD8＋ ratio of observation group were higher than those of control group （ P 〈 0. 05 ） , but no significant differences of serum phosphorus and alkaline phosphatase levels or CD4＋ , CD8＋ percentage was found between the two groups （P 〉 0. 05）. Conclusion Vitamin D therapy can improve the cellular immune function of type 2 diabetes mellitus patients complicated with respiratory tract infection, and is safe.

关 键 词：糖尿病 2型 呼吸道感染 维生素D 细胞免疫 

分 类 号：R587.1[医药卫生—内分泌] R517.6[医药卫生—内科学]