持续正压通气联合盐酸氨溴索治疗新生儿呼吸窘迫综合征的临床效果  

Clinical Effect of Continuous Positive Airway Pressure Ventilation Combined with Ambroxol Hydrochloride on Neonatal Respiratory Distress Syndrome

作　　者：李颖[1] 

机构地区：[1]广州中医药大学第一附属医院新生儿科,广东省广州市510000

出　　处：《临床合理用药杂志》2015年第3期81-82,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨持续正压通气联合盐酸氨溴索治疗新生儿呼吸窘迫综合征(NRDS)的临床效果。方法选取广州中医药大学第一附属医院新生儿科2011年1月—2014年2月收治的NRDS患儿140例,采用随机数字表法分为对照组和试验组,每组70例。对照组患儿采用吸氧与盐酸氨溴索联用治疗;试验组患儿则采用持续正压通气联合盐酸氨溴索治疗;比较两组患儿临床疗效、病死率,治疗前后血氧饱和度、心率及呼吸频率。结果对照组和试验组患儿治疗总有效率分别为67.1%、91.4%;两组差异有统计学意义(P<0.05)。对照组和试验组患儿病死率分别为18.6%、5.7%;两组差异有统计学意义(P<0.05)。两组患儿治疗后血氧饱和度高于治疗前,心率及呼吸频率低于治疗前(P<0.05);治疗后试验组患儿血氧饱和度高于对照组,心率及呼吸频率低于对照组,差异有统计学意义(P<0.05)。结论持续正压通气联合盐酸氨溴索治疗NRDS可有效减轻患者临床症状、体征,改善生命体征,并降低病死率。Objective To investigate clinical effect of continuous positive airway pressure ventilation combined with ambroxol hydrochloride on neonatal respiratory distress syndrome. Methods A total of 140 children with neonatal respiratory distress syndrome were chosen in department of Neonatology,the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,from January 2011 to February 2014,and they were randomly divided into control group and experiment group,70 cases in each group. Children of control group were treated with oxygen inhalation combined with ambroxol hydrochloride,while children of experiment group were treated with continuous positive airway pressure ventilation combined with ambroxol hydrochloride. Clinical efficacy,mortality and blood oxygen saturation,heart rate,respiratory rate before and after treatment between the two groups were compared. Results The total effective rate of experiment group and control group was 91. 4%,67. 1%,respectively,the difference was statistically significant（ P〈 0. 05）. The mortality of experiment group and control group was 5. 7%,18. 6%,respectively,the difference was statistically significant（ P 〈0. 05）. After treatment,blood oxygen saturation of the two groups were higher than before treatment,heart rate and respiratory rate were lower than before treatment,the differences were statistically significant（ P〈 0. 05）. After treatment,blood oxygen saturation of experiment group was higher than that of control group,heart rate and respiratory rate were lower than those of control group,the differences were statistically significant（ P 〈0. 05）. Conclusion Continuous positive airway pressure ventilation combined with ambroxol hydrochloride can efficiently relieve clinical symptoms and signs,improve vital signs and reduce mortality of children with neonatal respiratory distress syndrome.

关 键 词：呼吸窘迫综合征 新生儿 连续气道正压通气 盐酸氨溴索 治疗结果 

分 类 号：R722.1[医药卫生—儿科]