微创碎吸术手术时机对高血压脑出血患者血清IL-6、TNF-α水平的影响  

The influence of minimally invasive aspiration operation time on the clinical effect,serum IL-6,TNF-α level in patients with hypertensive cerebral hemorrhage

作　　者：房晓勇 郭春光 李志涛 房巧英 王金丽 张秋菊 李桂文 

机构地区：[1]河北省威县人民医院,054700

出　　处：《临床合理用药杂志》2015年第4期13-14,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的：探讨微创碎吸术手术时机对高血压脑出血患者血清IL-6、TNF-α水平的影响。方法将220例高血压脑出血患者随机分为观察组及对照组各110例。2组患者均常规给予脱水降颅内压、控制血糖和血压及神经营养支持等治疗。观察组患者脑出血6h内进行微创碎吸术手术，对照组患者脑出血6～24h内进行微创碎吸术手术。检测2组患者手术前后血清IL-6及TNF-α的含量水平，并比较2组的临床疗效。结果观察组总有效率为91．82％高于对照组的74．55％，差异有统计学意义（P＜0．05）。治疗前2组血清IL-6与TNF-α水平差异均无统计学意义（P＞0．05），治疗后，2组患者血清IL-6、TNF-α水平均显著低于治疗前，且随着治疗时间的延长，血清IL-6与TNF-α水平逐渐降低；治疗2、3、5、7d时观察组患者血清IL-6与TNF-α水平均低于对照组，差异均有统计学意义（ P＜0．05）。结论脑出血6h内进行微创碎吸术手术可提高高血压脑出血治疗有效率。Objective To explore the influence of minimally invasive aspiration operation time on the clinical effect, serum IL-6,TNF-α level in patients with hypertensive cerebral hemorrhage. Methods 220 patients with hypertensive cerebral hemorrhage were randomly divided into observation group and control group, 110 cases of each. All patients were treated by diu- resis dehydration, blood sugar and blood pressure control, neurotrophic therapy and other symptomatic treatment. The observa- tion group was received minimally invasive aspiration operation in 6 hours after hypertensive cerebral hemorrhage, while the control group was treated after hypertensive cerebral hemorrhage 6 hours but in 24 hours. The serum level of IL-6 and TNF-α, therapy effect of two groups were tested and compared the differences. Results Total effective rate of observation group （91.82%） was higher than that of the control group（74.55% ） ,the difference was statistically significant（P 〈0.05）. Before the treatment, the difference between the 2 groups of serum IL-6 and TNF-α level had no statistical significance （ P 〉 0.05 ）. After treatment, the serum levels of two groups were significantly lower than that before treatment, and with the extension of treatment time, serum IL-6 and TNF-α levels decreased gradually. The serum IL-6 and TNF-α levels in treatment of 2, 3, 5,7d were lower than the control group,the differences were statistically significant（P 〈 0.05）. Conclusion Taking the minimally invasive aspiration operation within 6 hours after hypertensive cerebral hemorrhage can improve the effectiveness.

关 键 词：微创碎吸术 手术时机 高血压脑出血 IL-6 TNF-Α 

分 类 号：R651.1[医药卫生—外科学]