防芷鼻炎片的质量标准提高研究  

Quality standard of Fangzhi Biyan tablets

作　　者：员荣 孙丽丽 杨立伟 陈锋 隆颖 

机构地区：[1]广东药学院,广州510006 [2]广东省食品药品检验所,广州510180

出　　处：《中南药学》2015年第1期83-86,共4页Central South Pharmacy

摘　　要：目的建立防芷鼻炎片的质量标准,为2015年版中国药典修订提供数据资料。方法采用薄层色谱法对方中野菊花、防风、苍耳子、白芍进行定性鉴别,建立防芷鼻炎片中蒙花苷含量的HPLC测定方法。结果薄层色谱鉴别专属性强,斑点清晰,蒙花苷与其他成分能达到良好的分离,在0.040 99~0.614 9μg内与峰面积线性关系良好（r=0.999 9,n=5）,平均回收率在101.7%~103.5%（n=3）。结论建立的方法简便,所得结果可靠,适用于防芷鼻炎片的质量控制。Objective To establish a method for the quality control of Fangzhi Biyan tablets, to provide data for Chinese Pharmacopoeia 2015 Edition. Methods Thin-layer chromatography（TLC） was used for the qualification of Wild chrysanthemum, Saposhnikovio divaricate, Fructus xanthil and Radix Paeoniae Alba, and the content of linarin in Fangzhi Biyan tablets was determined by HPLC. Results TLC spots were clear and well-separated without interference from the negative sample： the calibration curve had a good linearity at 0.040 99- 0.614 9 μg（r = 0.999 9）（n = 5）, the average recovery of Fangzhi Biyan tablets was at 101.7%- 103.5%（n = 3）. Conclusion The method can be used to control the quality of Fangzhi Biyan tablets.

关 键 词：防芷鼻炎片 蒙花苷 高效液相色谱法 薄层色谱法 

分 类 号：R917[医药卫生—药物分析学]