过敏性紫癜患者血清超敏C反应蛋白、心肌酶谱和心肌肌钙蛋白Ⅰ的变化及其临床意义  

The clinical significance of hs-CRP and myocardial enzymes, cTn Ⅰ changes in allergic purpura patients with the myocardial injury

作　　者：刘黎霞[1] 苗丽[1] 

机构地区：[1]威海市文登中心医院心内二科,山东省威海264400

出　　处：《中国基层医药》2015年第2期235-237,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨过敏性紫癜患者血清超敏C反应蛋白（hs-CRP）、心肌酶谱和心肌肌钙蛋白Ⅰ（cTnⅠ）的变化及其临床意义.方法 选取过敏性紫癜患者100例,其中仅皮肤受累者50例作为单纯组,皮肤并伴有心肌受累者50例作为混合组,另外选择同期在该院健康体检的成年人50例作为对照组.检测并对比三组血清hs-CRP、心肌酶谱和cTn Ⅰ.结果 混合组和单纯组血清hs-CRP、心肌酶谱和cTn Ⅰ水平均明显高于对照组（均P＜0.05）;混合组血清肌酸激酶同工酶（CK-MB）、cTn Ⅰ和hs-CRP水平均明显高于单纯组（均P＜0.05）.过敏性紫癜患者中以cTn Ⅰ异常最多,CK-MB次之,分别占33％ （33/100）和32％ （32/100）,混合组血清CK-MB和cTn Ⅰ异常患者构成比明显高于单纯组（χ^2=4.047、3.908,均P＜0.05）;经Pearson相关系数分析显示：血清hs-CRP与CK-MBc、cTn Ⅰ水平存在直线关系,呈正相关（r=0.872、0.801,均P＜0.05）.结论 过敏性紫癜患者及尽早检测血清hs-CRP、心肌酶谱和cTn Ⅰ水平并及时针对心肌损害进行治疗.Objective To investigate the clinical significance of the changes of hypersensitive C-reactive protein （hs-CRP） and myocardial enzyme spectrum,cardiac troponin Ⅰ （cTn Ⅰ） in patients with Henoch-Schnlein purpura.Methods 100 patients with Henoch-Schnlein purpura were selected.50 patients only skin involved were selected as the simple group,50 patients accompanied by other organs involved were selected as mixed group.50 healthy people in the same period were selected as the control group.The serum hs-CRP,myocardial enzyme spectrum and cTn Ⅰ were tested and compared.Results The hs-CRP,serum myocardial enzyme spectrum and cTn Ⅰ levels of mixed and simple group were significantly higher than the control group（all P 〈 0.05） ; Serum CK-MB,cTn Ⅰ and hs-CRP levels of the mixed group were significantly higher than those of simple group （all P 〈 0.05）.The abnormalities number of CK-MB and cTn Ⅰ respectively accounted for 33% （33/100） and 32% （32/100） ;The constituent ratio of the number of abnormal serum CK-MB and cTn Ⅰ of the mixed group was significantly higher than the simple group （χ^2=4.047,3.908,all P 〈 0.05） ;The Pearson correlation analysis showed that the relationship between the serum hs-CRP and CK-MB,cTn Ⅰ levels was linear,which were positively correlated （r =0.872,0.801,all P 〈 0.05）.Conclusion Patients with allergic purpura should early detect the serum levels of hs-CRP,myocardial enzyme spectrum and cTn Ⅰ,and treat the myocardial injury in time.

关 键 词：紫癜 过敏性 C反应蛋白质 肌钙蛋白Ⅰ 心肌酶谱 

分 类 号：R554.6[医药卫生—血液循环系统疾病]