急性高原病发病前后血管内皮生长因子及其受体水平变化  

Study on vascular endothelial growth factor and its receptors levels before and after the onset of acute mountain sickness

作　　者：李萌博[1] 丁辉[2] 

机构地区：[1]武警北京总队医院内二科,100027 [2]武警后勤学院附属医院儿科,天津300162

出　　处：《中华灾害救援医学》2015年第1期9-11,15,共4页Chinese Journal of Disaster Medicine

摘　　要：目的探讨人群急进高原前后血管内皮生长因子(vascular endothelial growth factor,VEGF)和受体VEGFR-1(fms-like tyrosine kinase-1,flt-1)、VEGFR-2(fetal liver kinase-1/kinase insert domain-containing receptor,flk-1/KDR)的表达变化及其与急性高原病(acute mountain sickness,AMS)发病的关系,为发现和保护易感人群提供理论依据。方法以2000名健康新兵为研究对象,分别在急进高原前后抽取静脉血备用。以症状评分法调查急进高原后AMS的发病率,随机选取20名AMS发病对象为AMS组,20名未发病对象为对照组,采用ELISA法检测急进高原前后两组血浆VEGF、VEGFR-1、VEGFR-2浓度的变化。结果 2000名研究对象中AMS的发病率为34.3%。与平原地区相比,AMS组急进高原后血浆VEGF浓度明显升高且差异有统计学意义(t=2.799,P=0.011),血浆VEGFR-1和VEGFR-2浓度无明显变化;对照组急进高原后血浆VEGF、VEGFR-1和VEGFR-2浓度变化无统计学意义(P>0.05)。急进高原前后AMS组血浆VEGF浓度均明显高于对照组(t=2.461,P=0.018;t=2.698,P=0.010),而血浆VEGFR-1、VEGFR-2浓度与对照组相比均无明显差异。结论血浆VEGF浓度有可能作为一个敏感指标在急进高原前筛选AMS易感者,而血浆VEGFR-1、VEGFR-2浓度与AMS的发生无相关性。Objective To investigate the changes of vascular endothelial growth factor（ VEGF） and its receptors（ VEGFR-1and VEGFR-2） in plasma before and after emergent entering plateau and their relationship with acute mountain sickness（ AMS）,in order to provide a theoretical basis for identifying and protecting susceptible population. Methods 2000 healthy recruited soldiers were selected as research object,their venous blood were collected respectively before and after emergent entering plateau. AMS incidence was investigated with symptom score method,and 20 patients randomly selected as AMS group and 20 objects without AMS as control group,then plasma concentration of VEGF,VEGFR-1 and VEGFR-2 before and after emergent entering plateau by ELISA were examined respectively. Results The AMS incidence was 34. 3%. Compared with plain area,plasma VEGF concentration of AMS group increased significantly after emergent entering plateau,the difference was statistically significant（ t = 2. 799,P = 0. 011）,the changes of plasma VEGFR-1 and VEGFR-2 concentration were not obvious. Changes of plasma VEGF,VEGFR-1 and VEGFR-2 concentration in control group were meaningless（ P 〉 0. 05）. Plasma VEGF concentration of AMS group were significantly higher than that of control group both on plateau and in plain areas（ t = 2. 461,P = 0. 018; t = 2. 698,P = 0. 010）. The differences of VEGFR-1 and VEGFR-2 concentration between the two groups were not significant neither on plateau nor in plain. Conclusions Plasma VEGF concentration may serve as a tool in screening the people susceptible to AMS before emergent entering plateau. There is no correlation between plasma VEGFR-1,VEGFR-2 concentration and AMS.

关 键 词：急性高原病 血管内皮生长因子 受体 

分 类 号：R594.3[医药卫生—内科学] R3[医药卫生—临床医学]