不同生活环境藏族脂代谢的特点及与PON1、ox-LDL的关系  

Characteristics of Lipid Metabolism and its relationship with PON1 and ox-LDL in Tibetans the altitude of 3681m and 4800m

作　　者：代青湘[1] 许慧宁[1] 王红心[1] 李占全[1] 高继东[1] 杨爱荣[1] 仝海英[1] 尼玛 奥宫清人 

机构地区：[1]青海大学附属医院,810001 [2]青海省玉树县人民医院,812200 [3]日本综合地球环境研究所

出　　处：《青海医药杂志》2014年第11期1-4,共4页Qinghai Medical Journal

基　　金：青海大学附属医院中青年课题(项目号ASRF-2009-07)

摘　　要：目的:探讨高原地区不同生活环境下藏族人群血脂代谢特点及与对氧磷酶1(PON1)及氧化低密度脂蛋白(ox-LDL)变化的关系。方法:对青海省玉树县结古镇(城镇地区,平均海拔3 700m)和隆宝镇(纯牧业地区,平均海拔4 800m)176例藏族人群进行脂代谢的特点及与PON1、ox-LDL的关系进行研究分析。结果:1玉树地区高脂血症患病率为46.0%(81/176例),其中结古镇组高脂血症的患病率为60.2%(71/118例),显著高于隆宝镇组17.2%(10/58例);结古镇组高TC血症、高TG血症、高LDL血症的患病率分别为44.9%、25.4%和47.5%,显著高于隆宝镇组19.0%、5.2%和17.2%),P<0.01;2相关分析显示PON1与TC、TG呈负相关,ox-LDL与海拔及Hb呈正相关,P<0.01;3Logistic回归分析显示,影响脂质代谢的主要因素为年龄、住址(结古镇和隆宝镇)、Hb及腹围。结论:不同海拔不同生活环境藏族血脂水平与PON1及ox-LDL浓度不同,血脂增高是血浆PON1降低原因之一,海拔的差异性、城镇化生活环境、高龄及血红蛋白可能是高原地区藏族PON1及ox-LDL水平不同的一个影响因素。Objective： To investigate the characteristics of lipid metabolism and its relationship with paraoxonase 1（PON1） and low- density lipoprotein（ ox- LDL） in Tibetans at the different altitude. Methods： A total of 118 Tibetans（ aged 55.7 ± 12.9 years） residing at 3 700 m and 58 Tibetans（ aged 55.33 ± 9.45） residing at 4 800 m in Yushu area were selected in this study. According to the 2007 ＇China Adult Dyslipidemia Prevention Guideline＇,the plasma levels of PON1,ox- LDL,cholesterol（ TC）,triglycerides（ TG）,low- density lipoprotein cholesterol（ LDL- C）,and high-density lipoprotein cholesterol（ HDL- C） were measured by ELISA assay at two different altitudes mentioned above. Results： TC,TG,and LDL- C values were（ 185. 18 ± 64. 38） mg / d L,（ 118. 36 ± 95. 40） mg / d Land（ 116. 53 ± 53. 50） mg / d L,respectively in Jiegu Town Group. And these were significantly higher than those in Longbao Town Group（ 142. 69 ±59. 62） mg / d L,（ 52. 99 ± 51. 87） mg / d L and（ 81. 49 ± 49. 75） mg / d L,respectively,（ P〈 0. 001）. No significant difference was found in the HDL- C levels of both groups. The rate of hyperlipidemia in Jiegu group（ 59. 2%） was significantly higher than Longbao（ 22. 2%） group（ P〈0.01）. The hyperlipidemia involved TC,TG and LDL- C in Jiegu group were 44. 9%,25. 4% and 47. 5%,respectively,and 19. 0%,5. 2%,17. 2%,respectively,in Longbao group.Conclusion： Urbanized living environment of pastoral Tibetans is an important factor of increased blood lipids in the high altitude area. Hypoxic environment may be a factor to lipid oxidation in Tibetan people on the Plateau.

关 键 词：高原 藏族 不同环境 血脂 OX-LDL PON1 

分 类 号：R544.1[医药卫生—心血管疾病] R339.54[医药卫生—内科学]