胚胎干细胞体外分化为肝细胞和心肌细胞的研究进展  

Advances in research on in vitro differentiation of embryonic stem cell into liver cells and myocardial cells

作　　者：张兴[1] 申秀萍 刘昌孝[2,3] 

机构地区：[1]天津中医药大学,天津300193 [2]天津市新药安全评价研究中心,天津300193 [3]天津药物研究院天津药代动力学与药效动力学省部共建国家重点实验室,天津300193

出　　处：《药物评价研究》2014年第6期554-557,共4页Drug Evaluation Research

基　　金："重大新药创制"科技重大专项(2012XZ09505);973计划资助(2010CB735602);"十一五"国家科技支撑计划(2007BAI41B03)

摘　　要：胚胎干细胞是从早期胚胎或原始性腺分离后能在体外长期传代培养的全能细胞系。胚胎干细胞体外可以诱导分化为各种体细胞,并且用这些体细胞治疗相应的疾病,一直以来是生物医药领域的研究焦点。目前,在该领域用于诱导胚胎干细胞分化的方法很多,其中的一些方法就用到化合物和部分中药提取物。整理近5年来胚胎干细胞体外通过拟胚体途径、细胞单层诱导分化为肝细胞和心肌细胞的有关文献,做一简要综述。Embryonic stem cell, separated from the early embryo or the original gonad, is the all-around cell line, which can be well for long-term passages in vitro. Embryonic stem cells can be differentiated into all kinds of somatic cells in vitro and are used to heal relevant serious illnesses. It is a hot spot in the field of study on the embryonic stem cell. It is difficult to find the mechanism, although it is very important. Currently, there are a lot of methods used to induce embryonic stem cells, and some of which are used for the compounds and parts of traditional Chinese medicine extracts. The author has compiled the nearly five years＇ literature on embryonic stem cells differentiating into myocardial ceils and liver cells and reviewed to provide the reference.

关 键 词：胚胎干细胞 生物医药 拟胚体 定向分化 

分 类 号：R967[医药卫生—药理学]