酰胺质子转移磁共振成像在帕金森病诊断中的应用价值  

Feasibility of detecting parkinson's disease using amide proton transfer MR imaging

作　　者：李春媚[1] 王蕊[1] 周进元[2] 张晨[1] 苏闻[3] 陈敏[1] 

机构地区：[1]卫生部北京医院放射科,北京100730 [2]美国马里兰州巴尔的摩市约翰霍普金斯大学医学院放射科 [3]卫生部北京医院神经内科,北京100730

出　　处：《功能与分子医学影像学（电子版）》2014年第3期4-7,共4页Functional and Molecular Medical Imaging(Electronic Edition)

基　　金：十二五国家科技支撑计划项目(2012BAI10B04);国家自然科学基金国际(地区)合作与交流项目(812111480)

摘　　要：目的 探讨酰胺质子转移成像（APT）磁共振成像技术检出帕金森病（PD）的可行性.方法 27例PD患者（男17例,女10例,年龄54 ～ 77岁）和22例年龄及性别相匹配的正常对照者（男13例,女9例,年龄55 ～ 73岁）进行头部APT磁共振成像,测量双侧黑质、红核、苍白球、壳核和尾状核的酰胺质子不对称磁化转移率（MTRasym）,采用独立样本f检验比较PD患者与正常对照者各脑结构MTRasym （3.5 ppm）的差异.结果 PD患者组黑质的MTRym（3.5 ppm）低于正常对照组（分别为1.0％±0.2％和1.3％±0.2％,P=0.005）PD患者组苍白球、壳核和尾状核的MTRasym（3.5 ppm）高于正常对照组（分别为0.9％±0.1％、0.5％±0.2％,P＜ 0.001; 1.0％±0.1％、0.8％±0.2％,P=0.003; 1.1％±0.1％、0.7％±0.2％,P＜0.001）.结论 磁共振APT成像技术有可能成为评价PD患者脑代谢异常的有效手段.Objective To demonstrate the feasibility of using amide proton transfer （APT） MR imaging to detect Parkinson＇s disease （PD） patients at 3 Tesla. Methods 27 PD patients （17 men and 10 women; age range, 54-77 years） and 22 age-matched normal controls （ 13 men and 9 women; age range, 55-73 years） underwent APT MR imaging. The magnetic resonance ratio asymmetry （MTRasym） values at 3.5 ppm of bilateral substantia nigra, red nucleus, globus pallidus, putamen and caudate were measured on APT images. MTRasym （3.5 ppm） values of cerebral structures between PD patients and control subjects were compared with independent-samples t test. Results The MTRasym （3.5 ppm） value of the substantia nigra was significantly lower in PD patients than in normal controls （1.0% ± 0.2% vs. 1.3% ± 0.2%, P = 0.005）. In contrast, the MTRasym （3.5 ppm） values of the globus pallidus, putamen, and caudate were significantly higher in PD patients than in normal controls （0.9% ±0.1% vs. 0.5% ± 0.2%,P〈0.001; 1.0% ±0.1% vs. 0.8% ± 0.2%,P= 0.003; 1.1% ±0.1% vs. 0.7 % ± 0.2 %, P 〈 0.001, respectively）. Conclusions APT may be a useful tool to evaluate cerebral abnormal metabolite of PD.

关 键 词：磁共振成像 酰胺质子转移 帕金森病 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.5[医药卫生—诊断学]