巨噬细胞移动抑制因子、肿瘤坏死因子-α水平在2型糖尿病患者中的变化及与颈动脉粥样硬化和糖尿病肾病的相关性分析  

Analysis on correlation between changes in MIF,TNF-α level and type 2 diabetics patients and carotid atherosclerosis and diabetic nephropathy

作　　者：卓凤婷[1] 张丽婷[1] 高旭航 

机构地区：[1]中国人民解放军第180医院内分泌科,福建泉州362000

出　　处：《中国医学前沿杂志（电子版）》2014年第10期81-84,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的探讨巨噬细胞移动抑制因子(MIF)与肿瘤坏死因子-α(TNF-α)水平在2型糖尿病患者中的变化及其与颈动脉粥样硬化、糖尿病肾病的相关性。方法随机选取本院内分泌科2011年5月至2013年10月收治的98例2型糖尿病患者,根据是否有颈动脉病变分为非颈动脉病变组(54例)与颈动脉病变组(44例),另选取同期体检健康者40例作为对照组,测定三组研究对象的血脂、肾功能等指标,比较并分析三组研究对象MIF、TNF-α、颈动脉内膜中层厚度(IMT)的差异及相关性。结果三组研究对象甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较差异无显著性(P>0.05);空腹血糖(FPG)、糖化血红蛋白(HbΑ1c)、MIF、TNF-α、IMT水平及尿清蛋白/肌酐(Α/C)比值比较差异具有显著性(P<0.05);非颈动脉病变组、颈动脉病变组患者FPG、HbΑ1c、MIF、TNF-α水平及Α/C比值显著高于对照组(P<0.05);颈动脉病变组患者IMT水平显著高于对照组(P<0.05);MIF水平与IMT水平、Α/C比值呈显著正相关(r=0.399,P=0.000;r=0.547,P=0.000);TNF-α水平与IMT水平、Α/C比值呈显著正相关(r=0.340,P=0.001;r=0.383,P=0.000)。结论 MIF与TNF-α在糖尿病颈动脉病变患者中表达水平较高,可能与颈动脉粥样硬化及糖尿病肾病具有一定相关性。Objective To explore the correlation between changes in the expression level of macrophage migration inhibitory factor（MIF） and tumor necrosis factor-α（TNF-α） in type 2 diabetes patients and carotid atherosclerosis and diabetic nephropathy. Method 90 patients with type 2 diabetes admitted into the department of endocrinology of our hospital from October 2011 to May 2013 were randomly selected, and they were divided into non carotid artery lesion group（54 patients） and carotid artery lesion group（44 patients） according to the existence of carotid artery, and 40 healthy person undergoing physical examination during the same period were separately selected. The blood lipid, renal function and other indexes of patients in three groups were determined, and the difference and correlation between MIF, TNF-α and carotid artery intima-media thickness（IMT） in three groups were compared and analyzed. Result The comparisons in levels of triglyceride（TG）, total cholesterol（TC）, high density lipoprotein cholesterol（HDL-C）, low density lipoprotein cholesterol（LDL-C） of patients in three groups were not significantly different（P〉0.05）, and the comparisons in levels of fasting blood glucose（FPG）, glycosylated hemoglobin（HbΑ1c）, MIF, TNF-α, IMT, urinary albumin creatinine（Α/C） of patients in three groups were significantly different（P〈0.05）. The levels of FPG, HbΑ1c, MIF, TNF-α, Α/C of patients in non-carotid artery disease group and carotid artery disease groups were significantly higher than those of patients in control group（P〈0.05）, and the level of IMT in patients in carotid artery lesions group was significantly higher than that of control group（P〈0.05）. The level of MIF was positively related to MIF and A/C（r = 0.399, P = 0.000; r = 0.547, P = 0.000）, and the level of TNF-α was positively related to IMT and Α/C（r = 0.340, P = 0.001; r = 0.383, P = 0.000）. Conclusion The expression levels of MIF and TNF-α were significant in diabetic

关 键 词：巨噬细胞移动抑制因子 肿瘤坏死因子-Α 2型糖尿病 糖尿病肾病 颈动脉粥样硬化 

分 类 号：R587.2[医药卫生—内分泌]