胡椒碱的合成工艺优化  

Optimized Synthesis Process of Piperine

作　　者：刘同星[1] 刘倩雯[1] 王丽梅[1] 李建发[1] 

机构地区：[1]天津理工大学化学化工学院,天津300384

出　　处：《当代化工》2015年第2期258-260,284,共4页Contemporary Chemical Industry

摘　　要：介绍了胡椒碱合成路线的一条优化工艺,其中氨解反应采用三乙胺作为催化剂,反应收率由原来的2.37%提高到18%,反应时间由原来的40 h缩短为18 h。合成胡椒碱中氨解反应的最佳反应条件为:依次加入0.5 g甲醇钠、25 m L甲醇、1.0 g胡椒酸甲酯、3.44 g哌啶、0.73 g三乙胺于反应器中,80℃回流18 h。An optimized synthesis process of piperine was described. The process used triethylamine as catalyst for ammonolysis, the reaction yield was increased from 2.37% to 18%, and the reaction time was shortened from 40 h to 18 h. The optimal reaction conditions for ammonolysis were determined as follows： sodium methoxide 0.5 g, methanol 25 m L, methyl piperate 1.0 g, piperidine 3.44 g, triethylamine 0.73 g, the reflux temperature 80 ℃ and the reflux time 18 h.

关 键 词：胡椒碱 合成 优化 三乙胺 

分 类 号：TQ463[化学工程—制药化工]