黏蛋白在宫颈腺体病变的表达及意义  

The Mucious Expression and Significance in Endocervical Glandular Lesions

作　　者：秦玲[1] 宋鸿涛[1] 耿敬姝[1] 邱慧磊[1] 秦誉[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院病理科,黑龙江哈尔滨150081

出　　处：《现代生物医学进展》2014年第33期6502-6505,6572,共5页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金重大项目(D201316)

摘　　要：目的:研究不同级别宫颈腺体病变组织中黏蛋白MUC2、MUC5AC、MUC6、CD10的表达情况,进而分析其与宫颈腺体病变发生发展的关系。方法:将2005年2月至2012年2月于哈尔滨医科大学附属第二医院妇产科手术切除及活检的宫颈病变患者病理组织183例,根据国际妇产科学联盟(FIGO)标准分为宫颈微腺体增生(MGH)60例;宫颈腺体不典型增生(EGD)57例;宫颈腺癌(ECA)56例,以免疫组化法检测MUC2、MUC5AC、MUC6、CD10的表达情况。结果:MUC2和CD10的阳性细胞比例随着宫颈腺体病变程度级别的增高呈上升趋势(P=0.046),而MUC5AC的表达则随着宫颈腺体病变程度级别的增高呈下降趋势(P<0.001);MUC6在三种宫颈病变组织中均呈低表达,不具有显著性差异(P>0.05)。结论:黏蛋白表型可以作为评估宫颈腺体病变恶性潜能的有用的标记物。Objective： To evaluate the immunohistochemical expression of MUC2, MUC5 AC, MUC6, CD10, P53 and Ki-67 in cervical microglandular hyperplasia（MGH）, cervical glandular dysplasia（EGD） and cervical adenocarcinoma（ECA）, and to analyze the relationship between the malignant potential of cervical glandular lesions and the expressions of mucins. Methods： The immunohistochemical analysis was performed to evaluate the expression of MUC2, MUC5 AC, MUC6, CD10, P53 and Ki-67 in 60 cases of MGH, 57 cases of EGD and 56 cases of ECA, and the percentage of positive cells were scored. Results： The expression of MUC2 and CD10 increased from MGH to ECA, conversely, the MUC5 AC expression decreased from MGH to ECA. MUC6 showed low expression and no significant difference in three cervical glandular lesions（P〉0.05）. Conclusion： The mucious phenotype may be useful markers for evaluating malignant potential of cervical glandular lesions.

关 键 词：宫颈肿瘤 黏蛋白 肠化生 

分 类 号：R711.74[医药卫生—妇产科学]