降钙素原、IL-6及CRP诊断新生儿宫内细菌感染的临床价值  

Effect of Procalcitonin Combined With IL-6 and C-reactive Protein in Diagnosis of Intrauterine Bacterial Infection in Neonates

作　　者：樊秦娥 吴立兵[2] 金琳[1] 肖冰[1] 余蓓蓓[1] 

机构地区：[1]湖北省十堰市妇幼保健院妇产科,湖北十堰442000 [2]湖北医药学院附属太和医院核医学科,湖北十堰442000

出　　处：《现代生物医学进展》2014年第33期6538-6540,6547,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨降钙素原、IL-6及CRP对新生儿宫内细菌感染诊断的临床价值。方法:采用回顾性分析方法,对121例疑似宫内细菌感染的新生儿的相关临床资料进行比较分析。通过影像学或细菌学方法对患儿进行检查判定感染类型,并检测患儿脐血中的降钙素原、C-反应蛋白(CRP)和白细胞介素-6(IL-6)的水平。结果:在121例患儿中41例确定为细菌感染,IL-6(>100ng/L)与CRP(>10mg/L)联合对诊断新生儿宫内细菌感染的敏感性为90.1%,特异性为76.9%,阴性预测率为91.7%,阳性预测率为71.9%;与PCT结合后,诊断新生儿宫内细菌感染的敏感性升高至98.3%,特异性为67.8%,阴性预测率为99.2%,阳性预测率为57.0%。结论:脐血PCT可作为新生儿宫内细菌感染诊断的有效指标,可明显提高IL-6与CRP诊断新生儿宫内细菌感染的阴性预测值和敏感性,指导临床治疗。Objective： To evaluate the clinical value of procalcitonin combined with IL-6 and C-reactive protein in diagnosis of intrauterine bacterial infection in neonates. Methods： The clinical date of 121 neonates who were suspected cases of intrauterine bacterial infection were analyzed retrospectively. The level of PCT, IL-6 and CRP were detected and the intrauterine bacterial infection was proved by imaging and bacteriology. Results： In 121 neoates, 41 children were confirmed as intrauterine bacterial infection. The sensitivity value of IL-6（〉100ng/L） combined with CRP detection in diagnosis of NBI was 90.1%, the specificity was 76.9%, and the negative predictive rate was 91.7%, the positive predictive rate was 71.9%. When IL-6 and CRP combined with PCT was used in diagnosis of NBI, the sensitivity value was 98.3%, the specificity was 67.8%, the negative predictive rate was 99.2%, and the positive predictive rate was 57.0%. Conclusion： PCT can be used as the auxiliary diagnosis of intrauterine bacterial infection, and can enhance the negative predictive value and sensitivity of IL-6 combined with CRP in diagnosis of NBI.

关 键 词：降钙素原 C-反应蛋白 白介素-6 新生儿宫内细菌感染 

分 类 号：R722.13[医药卫生—儿科]