CdTe量子点固化多层膜测定华法林的研究  

Studies on the Determination Method of Warfarin Based on Multilayer Film of CdTe Quantum Dots

作　　者：石彦茹 闫宏涛[1] 

机构地区：[1]西北大学化学与材料科学学院,陕西西安710069

出　　处：《分析科学学报》2014年第5期713-717,共5页Journal of Analytical Science

基　　金：国家科技支撑计划(No.2010BAK67B12)

摘　　要：采用水热法制备了CdTe量子点（QDs）,并采用静电层层自组装技术成功制备了CdTe QDs聚二烯丙基二甲基氯化铵（PDDA）固化多层膜,建立了该固化多层膜测定抗凝药物华法林（Warfarin,WF）的荧光分析新方法。结果表明,在0.1∽10μmol/L范围内,相对荧光强度（F/F0）与华法林浓度（cWF）呈线性关系,相关系数（R2）和检出限（3σ/k）分别为0.9886和0.082μmol/L。该CdTe QDs/PDDA固化多层膜稳定性好、易储存、使用方便,可用于药物片剂中华法林含量的测定。A novel method for the determination of warfarin was developed based on multilayer film of CdTe quantum dots（QDs）in this paper.With the electrostatic layer-by-layer self-assembly technology,the multilayer film of CdTe QDs/PDDA was successfully prepared.The multilayer film of CdTe QDs/PDDA was applied for rapid determination of anticoagulant warfarin.The results showed that the linear range of warfarin concentration was 0.1-10μmol/L.The linear correlation coefficient（R2）and detection limit（3σ/k）was 0.9886 and 0.082μmol/L,respectively.This multilayer film of determination warfarin is good stability,easy to store and convenient.The proposed method has been successfully applied for the determination of warfarin in tablets.It provided a simple and practicable assay sensor for determination of warfarin.

关 键 词：CDTE量子点 静电层层自组装 多层膜 华法林 

分 类 号：O657.3[理学—分析化学]