血清C反应蛋白与胆红素相关关系的Meta分析研究  

Meta analysis study on correlation between C-reactive protein and bilirubin

作　　者：王鹏[1] 胡勇[1] 罗春华[1] 

机构地区：[1]三峡大学第一临床医学院湖北省宜昌市中心人民医院检验科,443003

出　　处：《山西医药杂志》2014年第20期2363-2365,共3页Shanxi Medical Journal

基　　金：湖北省教育厅自然科学研究计划(D20131308)

摘　　要：目的采用Meta分析的方法,评价基于相关系数的C反应蛋白与胆红素的相关性。方法计算机检索PubMed、Springerlink、EMbase、Cochrane数据库,检索时限均为1990年1月至2013年7月,查找关于C反应蛋白与胆红素相关性的文献。按照纳入排除标准筛选文献、提取资料并评价纳入研究的质量后,采用RevMan 5.2软件进行Meta分析。结果共检出相关文献363篇,最终仅纳入质量较高的6篇文献。Meta分析结果显示,C反应蛋白与胆红素有一定负相关。结论 C反应蛋白与胆红素存在相关关系,可以作为有限反映慢性血管炎症的指标。Objective Meta analysis method was applied to evaluate the correlation between C-reactive protein and bilirubin based on correlation coefficient.Methods Literatures related to correlation between C-reactive protein and bilirubin from January 1990 to July 2013 were retrieved from PubMed,Springerlink,EMbase and Cochrane database.After screening literatures,extracting data and assessing the quality of studies according to inclusion and exclusion criteria,RevMan 5.2software was adopted to do Meta-analysis.Results Three hundred and sixty-three relevant literatures were retrieved,and finally only six literatures of high quality were included.Metaanalysis showed that there is negative correlation between C-reactive protein and bilirubin.Conclusion Correlation between C-reactive protein and bilirubin can be taken as limited indicators to reflect chronic vascular inflammation.

关 键 词：C反应蛋白质 胆红素 META分析 

分 类 号：R446.1[医药卫生—诊断学]