河南省2012年育龄期妇女乙肝血清学调查及风险因素分析  

A serological survey of hepatitis B virus and risk factors among women of child-bearing age in Henan Province,2012

作　　者：郭永豪[1] 李军[1] 刘倩[1] 徐瑾[1] 封秀红[1] 叶莹[1] 董蒲梅[1] 张延炀[1] 刘国华[1] 

机构地区：[1]河南省疾病预防控制中心免疫规划所,河南郑州450016

出　　处：《中华疾病控制杂志》2014年第7期601-605,共5页Chinese Journal of Disease Control & Prevention

摘　　要：目的了解河南省现阶段育龄期妇女乙型病毒性肝炎（乙肝）病毒表面抗原[hepatitis B virus（HBV）surface antigen,HBsAg]、抗乙肝病毒表面抗原抗体（antibody to HBsAg,anti-HBs）、乙肝病毒e抗原（HBV e antigen,HBeAg）、抗乙肝病毒e抗原抗体（antibody to HBeAg,anti-HBe）的流行情况。方法用血清流行病学分析方法,在河南省多阶段随机抽取15~49岁常住人口,采集调查对象静脉血5 ml,统一检测HBsAg、抗-HBs。HBsAg阳性者再进一步检测HBeAg和抗HBe;对15~49岁育龄期妇女进行HBsAg及HBeAg流行状况分析。结果河南省育龄期妇女HBsAg流行率为3.77%,抗-HBs流行率为28.53%。在HBsAg阳性育龄期妇女中,HBeAg流行率为24.58%,抗HBe流行率为73.65%。育龄期妇女HBsAg流行率在城乡和文化程度之间的差异均有统计学意义（均有P〈0.05）。结论河南省现阶段,育龄期妇女HBsAg流行率低于河南省一般水平。Objective To get the prevalence of hepatitis B virus（ HBV） surface antigen（ HBsAg）,antibody to HBsAg（ anti-HBs）,HBV e antigen（ HBeAg） and antibody to HBeAg（ anti-HBe） of the child-bearing women in Henan. Methods Participants aged from 15 to 49 years were selected by multiple-stage sampling randomly from Henan and 4ml blood were drawn from each participant. The data of child-bearing women with 15-49 years of age were collected,HBsAg,antiHBs and anti-HBc were detected by ELISA. The HBsAg positive sample were also detected for HBeAg and HBeAb. Results The adjusted prevalence of HBsAg and anti-HBs were 3. 77% and 28. 53%,respectively. Among the HBsAg positive women,the adjusted prevalence of HBeAg and anti-HBe were 24. 58% and 73. 65%,respectively. There were significant differences in HBsAg prevalence between city and rural,nationality and education. Conclusions In Henan,the prevalence of HBsAg was 3. 77% in child-bearing women,which is lower than that in the whole population in Henan.

关 键 词：妇女卫生保健服务 肝炎 乙型 危险因素 

分 类 号：R512.62[医药卫生—内科学] R183[医药卫生—临床医学]