标准化耐多药肺结核化疗方案的不良反应及治疗转归情况分析  

Analysis on adverse drug reactions and treatment outcome of standardized therapy for multidrug resistant tuberculosis in Jiangsu Province

作　　者：孔雯[1] 刘巧[1] 陆伟[1] 丁晓艳[1] 

机构地区：[1]江苏省疾病预防控制中心慢性传染病防治所,江苏南京210009

出　　处：《中华疾病控制杂志》2014年第7期610-612,共3页Chinese Journal of Disease Control & Prevention

基　　金：卫生部科研基金(W201208)

摘　　要：目的分析江苏省标准化耐多药肺结核化疗方案不良反应发生情况及其对治疗转归的影响,为全省开展耐多药肺结核防治工作提供经验。方法选择江苏省两市采用标准化耐多药肺结核化疗方案治疗、且有明确治疗转归的81例耐多药肺结核患者为研究对象,对患者治疗后发生不良反应情况开展调查,并对不同治疗转归的患者进行统计分析。结果 89例完成治疗的患者中,81例(91.0%)使用标准化治疗方案,其中出现不良反应患者数为50例(61.7%)。发生不良反应的患者治疗依从率为76.0%,未发生不良反应的患者治疗依从率为90.3%,两者间差异无统计学意义(2=2.60,P=0.107)。发生不良反应的患者治疗成功率为56.0%,而未发生不良反应的患者治疗成功率为80.6%,两者间差异有统计学意义(2=5.14,P=0.023)。结论标准化抗结核方案在临床治疗中值得推广使用,但患者的不良反应率稍高,此研究对全省耐多药工作提供一定的参考价值。Objective To analyze the adverse drug reactions and treatment outcome of multi-drug-resistant tuberculosis（ MDR-TB）,and to provide experience for MDR-TB control in Jiangsu Province. Methods 81 MDR-TB cases were enrolled in this study. Therapeutic regimen,adverse reactions of anti-TB drug and treatment outcome of TB cases were analysed. Results Among the 89 patients who had completed whole treatment process,81（ 91. 0%） patients used standardized treatment. The adverse drug reactions rate was 61. 7%（ 50 /81）. Treatment adherence rates for cases with drug adverse reaction and for cases without drug adverse reaction were 76. 0% and 90. 3%,respectively,and there was no significant difference（ χ2= 2. 60,P = 0. 107）. The success treatment rates for cases with drug adverse reaction and for cases without drug adverse reaction were 56. 0% and 80. 6%,respectively,and there was significant difference between the two rates（ χ2= 5. 14,P = 0. 023）. Conclusions The standardized treatment of MDR-TB is recommended. Although,the slightly high adverse drug reaction may be noted. The present study provided evidences and experiences for MDR-TB treatment in Jiangsu Province.

关 键 词：结核 肺 广泛耐药结核 流行病学研究 

分 类 号：R521[医药卫生—内科学] R183[医药卫生—临床医学]