Bcl-2基因多态性与子宫内膜异位症的关系  

Association between Bcl- 2 gene polymorphism and endometriosis.

作　　者：郝双[1] 宗利丽[2] 林蒋海[3] 刘泽寰[3] 付永贵[4] 毛婷[5] 王玉凤[6] 赵欣[7] 

机构地区：[1]南方医科大学珠江医院妇产科,广州510282 [2]广州医科大学附属第一医院妇科,广州510120 [3]暨南大学生命与健康工程研究院分子生物研究中心,广州510632 [4]中山大学生命科学院国家重点医药分子生物学实验室,广州510275 [5]广东省妇幼保健院妇产科,广州510010 [6]广东省广州市红十字会医院妇产科,510220 [7]粤北人民医院妇产科,广东韶关512026

出　　处：《广东医学》2014年第14期2168-2171,共4页Guangdong Medical Journal

基　　金：国家自然科学基金资助项目(编号:30801012)

摘　　要：目的探讨B细胞淋巴瘤/白血病-2(Bcl-2)基因多态性与子宫内膜异位症的相关性。方法采用等位基因特异性PCR联合DNA测序对337例无子宫内膜异位症妇女(对照组)和302例子宫内膜异位症患者(病例组)Bcl-2基因rs1088477A/G和rs2279115A/C单核苷多态性进行基因分型。结果对照组妇女和病例组妇女rs1800477A/G位点AA、AG、GG基因型频率分别为1.3%、7.3%、91.4%和0.6%、8.6%、90.8%,两组间基因型分布的差异无统计学意义(P>0.05);对照组妇女和病例组妇女rs2275115A/C位点AA、AC、CC基因型频率分别为22.0%、45.1%、32.9%和25.8%、42.1%、32.1%,两组间基因型分布的差异亦无统计学意义(P>0.05)。结论 Bcl-2基因rs1800477A/G和rs2279115A/C单核苷酸多态性可能与子宫内膜异位症的易感性无关。Objective To investigate the association between risk of endometriosis and B- cell lymphoma- 2（Bcl-2） gene polymorphism. Methods The genotypes of Bcl-2 gene rs1800477A/G and rs2279115A/C in337 control individuals（without endometriosis） and 302 case individuals（endometriosis） were identified by allele specific- polymerase chain reaction（AS- PCR） and DNA sequencing. Results The frequencies of genotype AA,AG and GG of Bcl- 2gene rs1800477 A /G were 1. 3%,7. 3% and 91. 4%,respectively,in control group; while were 0. 6%,8. 6% and90. 8%,respectively in case group; with no significant difference between the 2 groups. The frequencies of genotype AA,AC and CC of Bcl- 2 gene rs2279115 A /C were 9. 7%,44. 6% and 45. 7%,respectively,in control group; while were25. 8%,42. 1% and 32. 1%,respectively,in case group; with no significant difference between the 2 groups. Conclusion There is no association between endometriosis and rs1800477 A /G or rs2279115 A /C polymorphism of Bcl- 2 gene.

关 键 词：子宫内膜异位症 BCL-2基因 单核苷酸多态性 

分 类 号：R711.71[医药卫生—妇产科学]