高感度活性稀释剂丙烯酰吗啉的合成研究  

Study on the synthesis of acryloyl morpholine as sensitivity active diluent

作　　者：宋国强[1] 罗九艳 李贝贝[1] 唐龙[1] 王羚竹[1] 

机构地区：[1]常州大学制药与生命科学学院,江苏常州213164

出　　处：《应用化工》2014年第7期1211-1213,共3页Applied Chemical Industry

基　　金：江苏省科技成果转化专项资金项目(BA2012062)

摘　　要：以二乙胺、丙烯酸甲酯为原料，经迈克尔加成，生成3-甲氧基-二乙基丙烯酸甲酯（产物Ⅰ），再与吗啉酰胺化生成3-吗啉基-二乙基丙酰胺（产物Ⅱ），最后经催化裂解得到丙烯酰吗啉。研究了投料比、反应温度、反应时间等因素对中间产物Ⅱ反应影响。结果表明，最佳反应条件为：产物Ⅰ、吗啉与甲醇钠摩尔投料比1：1.2：0.2，反应温度80~90℃，反应时间5~6 h，产物Ⅱ纯度可达82%，收率可达88%。产物Ⅱ再经催化裂解得目标产品丙烯酰吗啉，浓度约50%，收率约35%。3-Methoxy-ethyl ProPionate（Ⅰ）was synthesized by Michael addition with diethylamine and methyl acrylate. Therefore,comPoundⅠwas converted to 3-morPholin-diethyl ProPionamide（Ⅱ）by ami-dation with morPholine. Finally,acryloyl morPholinein was obtained by catalytic cracking of intermediatesⅡ. The effect of the ratio of raw material,reaction temPerature and time on intermediates Ⅱwere investi-gated. Result showed that the oPtimum reaction condition were as follows：the Purity of the intermediatesⅡ was uP to 82% and the yield was uP to 88%,when the molar ratio of 3-methoxy-ethyl ProPionate to morPholine and sodium methylate was 1：1 . 2：0 . 2 ,and the best reaction temPerature was 80~90 ℃,the best reaction time was 5~6 h. The Purity of acryloyl morPholine as the target Product was uP to 50% and the yield was uP to 35%.

关 键 词：丙烯酰吗啉 吗啉 二乙胺 丙烯酸甲酯 热解法 

分 类 号：TQ630.6[化学工程—精细化工]