氨氯地平联合坎地沙坦治疗高血压伴糖尿病63例疗效观察  

Effects of amlodipine combined with candesartan on the patients with hypertension and diabetes

作　　者：李喆[1] 王清传[2] 姚娟[3] 

机构地区：[1]海军医学研究所,上海200433 [2]新疆军区机关医院内科 [3]新疆维吾尔自治区人民医院心内科

出　　处：《海军医学杂志》2014年第5期387-389,共3页Journal of Navy Medicine

摘　　要：目的观察氨氯地平联合坎地沙坦治疗高血压伴糖尿病63例临床疗效。方法选取2009年2月至2012年10月来新疆军区机关门诊部和新疆维吾尔自治区人民医院心内科就诊的126例高血压伴糖尿病蛋白尿患者,所有患者签署知情同意书,并经医院伦理委员会批准,按数字表法随机分成对照组和联合组,每组63例。2组均给予常规降糖治疗,对照组给予氨氯地平5 mg,1次/d;治疗组在此基础上加服坎地沙坦8 mg,1次/d,如1周后血压仍≥140/90 mmHg则坎地沙坦加至8mg,2次/d,疗程均为6个月。观察2组患者治疗后血压、空腹血糖、血肌酐、尿素氮以及24 h尿蛋白的变化。结果 2组患者经治疗后,血压较治疗前均显著降低(P<0.05),联合组下降更明显(P<0.05);2组血肌酐、尿素氮及24 h尿蛋白较治疗前均有降低,且联合组明显低于对照组(P<0.05)。结论氨氯地平联合坎地沙坦不仅能有效控制血压,且可降低高血压伴糖尿病患者血肌酐、尿素氮及尿蛋白水平,能更有效保护肾功能。Objective To observe the effects of amlodipine combined with candesartan on the patients with hypertension and diabetes. Methods One hundred and twenty-six cases of hypertension complicated with diabetes from the medical data in the Clinic of the Xinjiang Military Command and the Cardiology Department of the Xinjiang Uygur Autonomous Region from February 2009 to October 2012 were chosen as our study subjects. With the knowledge and consent of the patients and following approval by the Hospital Ethics Committee,the patients were randomly divided into the control group and the combined treatment group,each consisting 63 patients. The patients in both groups were all given routine drugs for the control of glycemia,while the patients in the control group received amlodipine with a dosage of 5 mg,once a day. The patients in the combined treatment group were given candesartan with a dosage of 8mg,once a day,in addition to routine drugs. If the blood pressure of the patients was still higher than 140 /90 mmHg following 1 week of treatment,the application of candesartan was increased to twice a day also at a dosage of 8mg. The treatment course for the patients of both groups was all 6 months. Observations were made on the changes in blood pressure,fasting glucose,serum creatine,urinary nitrogen and 24-hour urinary protein. Results The blood pressure of the patients in both groups was all significantly decreased after treatment（ P〈0. 05）,with the blood pressure of the patients in the combined treatment group decreased more significantly（ P〈0. 05）. The levels of serum creatine,urinary nitrogen and 24-hour urinary protein in the patients of both groups were all decreased,when compared with those before treatment,and they were significantly lower than those of the control group（ P〈0. 05）. Conclusion Treatment with amlodipine combined with candesartan could not only control blood pressure effectively,but reduce serum creatine,urinary nitrogen and 24-hour urinary protein in patients with hypertension complica

关 键 词：氨氯地平 坎地沙坦 高血压 糖尿病 

分 类 号：R567.4[医药卫生—呼吸系统]