雷公藤多甙片药理学研究进展及临床应用  

A Review of Pharmacological Research Progress and Clinical Use on Multi-glycoside of Tripterygium wilfordi Hook,f Tablet

作　　者：张鑫[1] 武祯[1] 李航[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院肾内科,北京100730

出　　处：《临床药物治疗杂志》2014年第4期8-13,共6页Clinical Medication Journal

摘　　要：目的:综述雷公藤多甙片近年的药理学研究进展及临床应用。方法:搜集相关最新发表的文章,分析总结雷公藤的药理作用及临床应用进展。结果和结论:雷公藤多甙片主要有效成分为雷公藤内酯醇,体内代谢主要依赖细胞色素CYP450酶系作用。雷公藤内酯醇具有抗炎、免疫抑制、保护肾脏足细胞等作用。应用雷公藤多甙片治疗原发或继发性肾小球疾病,降低尿蛋白作用显著,不良反应主要为生殖系统损害、肝肾损害等。雷公藤多甙片价格低廉,效费比高,但制剂质量不稳定,影响临床应用。Objective： To summarize the recent pharmacological research progress and clinical use of Multi-glycoside of Tripterygiurn wilfordi Hook,f.（GTW）. Methods： We collected the latest researches related to the pharmacological reaction and clinical use of GTW, and then gave the analysis and summary. Results and Conclusion： Triptolide, as the major active component of GTW, is converted into metabolites in vivo through cytochrome P450 system. Triptolide has the effect of anti-inflammation, immunosuppression, and podocyte protection, etc. GTW can effectively reduce proteinuria when used in treating primary or secondary glomerulonephritis. The main adverse reactions are genital system damage and renal or hepatic damage. GTW is cheap and has a high cost-benefit ratio. But the pharmaceutical quality of GTW is unstable, which impactsits clinical use.

关 键 词：雷公藤多甙片 药理学研究 临床应用 不良反应 药物经济学 

分 类 号：R692.3[医药卫生—泌尿科学]