上海市浦东新区弯曲菌流行状况及耐药性分析  

Prevalence and antimicrobial susceptibility of Campylobacteria in diarrhea patients of Pudong district

作　　者：黄红[1] 王闻卿 傅惠琴[1] 苏靖华 张勇琪 赵冰[1] 

机构地区：[1]上海市浦东新区疾病预防控制中心,上海200136

出　　处：《中国卫生检验杂志》2014年第13期1961-1963,共3页Chinese Journal of Health Laboratory Technology

基　　金：浦东新区卫生局科技项目(PW2011B-11);上海市浦东新区卫生系统重点学科建设(PWZxk2010-09)

摘　　要：目的了解上海市浦东新区腹泻人群中弯曲菌感染流行状况和耐药性情况,为正确评价腹泻病人中弯曲菌的流行和制定切实可行的预防措施提供依据。方法采用改良培养分离方法对2011年6月-2012年5月间浦东新区13家监测点医院感染性腹泻人群进行进行弯曲菌监测。结果在2 532份标本中,共分离到弯曲菌127株,其中空肠弯曲菌106株,阳性率4.19%;结肠弯曲菌21株,阳性率0.83%;中心城区感染率高于郊区,春秋季感染显著高于夏季(χ2=12.17,P<0.01)。106株空肠弯曲菌分离株对14种抗生素高度敏感的是阿奇霉素91.04%,红霉素86.57%;高度耐药的是:头孢西丁98.51%,奈啶酸97.76%,复方新诺明96.27%,头孢呋辛92.54%,诺氟沙星91.79%。结论浦东新区腹泻病人中弯曲菌成为腹泻病原谱的主要病原,耐药性相当严重。Objective To know the prevalence and antimicrobial susceptibility of Campylobacter Spp.in diarrhea patients in Pudong new district of Shanghai,and provide foundation for evaluating the epidemic trend of Campylobacter Spp.and making viable control measures.Methods From June 2011 to May 2012,infectious diarrhea patients of 13 monitoring hospitals were involved to detect the Campylobacter using modified culture and separation method.Results A total of 127 Campylobacter strains were isolated from 2 532 diarrhea specimens,including 106 Campylobacter jejuni isolates（4.19%） and 21 Campylobacter coli isolates（0.83%）.The infection rate was higher in urban area than suburban area,higher in spring and autumn than summer（χ2= 12.17,P〈0.01）.The 106 Campylobacter jejuni isolates were highly sensitive to azithromycin（91.04%）,followed by erythromycin（86.57%）,but highly resistant to cefoxitin（98.51%）,followed by nalidixic acid（97.76%）,co-trimoxazole（96.27%）,cefuroxime（92.54%）,norfloxacin（91.79%）.Conclusion The Campylobacter has been one of the most important pathogens in diarrhea crowd in Pudong new area,and the antibiotic resistance is quite serious.

关 键 词：空肠弯曲菌 结肠弯曲菌 腹泻 抗生素耐药 

分 类 号：R378.99[医药卫生—病原生物学]