不健康生活方式对男性冠心病患者支架内再狭窄的影响  

Inflence of nhealthy lifestyle on in-stent restenosis in male patients after perctaneos coronary intervention

作　　者：闫哲[1] 豆颖[2] 孙福成[3] 

机构地区：[1]河南省商丘市第一人民医院心内科,476100 [2]河南省商丘市第一人民医院病理科,476100 [3]卫生部北京医院心内科

出　　处：《中国实用医药》2014年第20期14-16,共3页China Practical Medicine

基　　金：商丘市科技攻关计划项目资助(项目编号:141052)

摘　　要：目的观察不健康生活方式对男性冠心病患者支架内再狭窄的影响。方法回顾性分析行冠状动脉介入治疗的男性冠心病患者共计170例。根据患者有无不健康生活方式分为A组和B组。A组患者98例,有不健康生活方式,如高脂饮食、吸烟、熬夜、运动少。B组患者72例,经调查患者无不健康生活方式。两组患者均进行常规药物治疗,药物治疗依从性良好。测量术前、术后即刻和9个月随访最小管腔直径(MLD),支架植入部位参考血管直径(RD)、再狭窄率(DS);统计分析患者靶病变血运重建率(TLR)和靶血管血运重建率(TVR)。检测患者血总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)。结果术后9个月随访两组支架内最小管腔直径[(1.3±1.0)mm VS(2.4±0.4)mm]和再狭窄率[(56±33)%VS(20±8.3)%],差异有统计学意义(P<0.05)。A组随访9个月TLR为15.4%,TVR为14.6%;B组随访9个月TLR为6.2%,TVR为3.8%。两组在TLR和TVR差异有统计学意义(P<0.05)。A组和B组两组总胆固醇、低密度脂蛋白、甘油三酯[(5.26±1.06)VS(4.36±1.14)mmol/L;(2.87±0.84)VS(2.46±0.65)mmol/L;(2.66±1.30)VS(1.96±1.11)mmol/L],差异有统计学意义(P<0.05)。结论不健康生活方式增加男性冠心病患者支架内再狭窄率、靶病变血运重建率和靶血管血运重建率。Objective To evaluate the relationship between unhealthy lifestyle and in-stent restenosis in male patients with coronary artery disease after percutaneous coronary intervention.MethodsDivided 170 patients with coronary artery into group A（unhealthy lifestyle, n=98） and group B（healthy lifestyle, n=72）. At baseline, post-stenting and at follow-up, minimal luminal diameter（MLD）, reference vessel diameter（RD）, and diameter stenosis（DS） were measured, respectively. We analyzed nine-month TLR and TVR. Total cholesterol, high-density lipoprotein, triglycerides and low-density lipoprotein were measured.ResultsAt 9 months, statistically significant difference was observed in minimal luminal diameter（MLD） and diameter stenosis （DS %） between group A and group B[（1.3±1.0） vs （2.4±0.4）mm, （56±33） vs （20±8.3）%,P〈0.05]. There was also statistically significant difference in the rate of TVR and TLR between group A and group B（14.6% vs 3.8%,15.4% vs 6.2%,P〈0.05）. TC, LDL-C and TG were significantly higher in group A compared to group B at baseline[（5.26±1.06） mmol/L vs （4.36±1.14）mmol/L;（2.87±0.84）mmol/L vs（2.46±0.65）mmol/L;（2.66±1.30） mmol/L vs（1.96±1.11）mmol/L,P〈0.05].ConclusionUnhealthy lifestyle increases rate of in-stent restenosis, TLR and TVR.

关 键 词：不健康生活方式 支架内再狭窄 冠心病 经皮冠状动脉介入治疗 

分 类 号：R541.4[医药卫生—心血管疾病]