枸橼酸钙治疗骨质疏松症的药物经济学评价  

Pharmacoeconomics evaluation of calcium citrate in the treatment of osteoporosis

作　　者：谭慧 袁浩宇 季平 

机构地区：[1]雅安市中医医院,四川雅安625000 [2]核工业416医院,四川成都610051

出　　处：《现代医药卫生》2014年第15期2266-2267,共2页Journal of Modern Medicine & Health

摘　　要：目的比较枸橼酸钙和碳酸钙治疗骨质疏松症的疗效,并进行药物经济学评价。方法选择2012年12月至2013年12月该院门诊治疗的骨质疏松症患者180例,随机分为A、B两组,每组90例。A组口服枸橼酸钙,B组口服碳酸钙。观察两组疗效和不良反应,并运用成本-效果比(C/E)进行分析。结果枸橼酸钙总有效率为85.56%,碳酸钙总有效率为83.33%,两组比较,差异无统计学意义(P>0.05)。枸橼酸钙组不良反应发生情况低于碳酸钙组,差异有统计学意义(P<0.05)。两组C/E比较,差异无统计学意义(P>0.05)。结论枸橼酸钙和碳酸钙治疗骨质疏松症的药物疗效和成本相似,但枸橼酸钙不良反应发生情况更少。Objective To compare the clinical efficacy of calcium citrate and calcium carbonate in treating osteoporosis and to evaluate the pharmacoeconomics. Methods A total of 180 patients with osteoporosis who were treated in the hospital from December 2012 to December 2013 ,were randomly divided into group A and group B ,90 cases in each group. The group A was with oral calcium citrate,while the group B were administrated with calcium carbonate orally. Clinical efficacy and adverse reac-tion in the two groups were observed,and analyzed by cost-effect ratio（C/E）. Results The total effective rate was 85.56%of calcium citrate and 83.33% of the calcium carbonate,and the difference between the two groups had no statistical significance（P〉0.05）. The incidence rate of adverse reaction of calcium citrate was lower than that of calcium carbonate with statistically significant difference（P〈0.05）. There was no statistically significant difference on E/C between the two groups（P〉0.05）. Conclusion Calci-um citrate and calcium carbonate have similar efficacy and cost-effec tiveness in the treatment of osteoporosis ,but the incidence rate of adverse reaction of calcium citrate is lower.

关 键 词：钙/治疗应用 骨质疏松/药物疗法 柠檬酸盐类/治疗应用 成本-效果比分析 

分 类 号：R681[医药卫生—骨科学]